Biological sensing with magnetic nanoparticles using Brownian relaxation (invited)

S. H. Chung; A. Hoffmann; K. Guslienko; S. D. Bader; C. Liu; B. Kay; L. Makowski; L. Chen

doi:10.1063/1.1853694

Biological sensing with magnetic nanoparticles using Brownian relaxation (invited)

S. H. Chung, A. Hoffmann, K. Guslienko, S. D. Bader, C. Liu, B. Kay, L. Makowski, L. Chen

Research output: Contribution to journal › Article › peer-review

Abstract

Magnetic nanoparticles coated with biochemical ligands are enabling many biological and medical applications. In particular biomagnetic sensors have potential advantages of simplicity and rapidity. We demonstrate a substrate-free biomagnetic sensing approach using the magnetic ac susceptibility of ferromagnetic particles suspended in a liquid. The magnetic relaxation of these particles is mainly due to Brownian rotational diffusion, which can be modified by binding the particles to the intended target. This scheme has several advantages: (i) it requires only one binding event; (ii) there is an inherent check of integrity; and (iii) the signal contains additional information about the target size.

Original language	English (US)
Article number	10R101
Journal	Journal of Applied Physics
Volume	97
Issue number	10
DOIs	https://doi.org/10.1063/1.1853694
State	Published - May 15 2005
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy(all)

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10.1063/1.1853694

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abstract = "Magnetic nanoparticles coated with biochemical ligands are enabling many biological and medical applications. In particular biomagnetic sensors have potential advantages of simplicity and rapidity. We demonstrate a substrate-free biomagnetic sensing approach using the magnetic ac susceptibility of ferromagnetic particles suspended in a liquid. The magnetic relaxation of these particles is mainly due to Brownian rotational diffusion, which can be modified by binding the particles to the intended target. This scheme has several advantages: (i) it requires only one binding event; (ii) there is an inherent check of integrity; and (iii) the signal contains additional information about the target size.",

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AU - Chung, S. H.

AU - Hoffmann, A.

AU - Guslienko, K.

AU - Bader, S. D.

AU - Liu, C.

AU - Kay, B.

AU - Makowski, L.

AU - Chen, L.

N1 - Funding Information: This work was supported by the U. S. Department of Energy, Basic Energy Sciences-Materials Science, under Contract No. W-31-109-ENG-38 and DARPA, under Contract No. 8C67400.

PY - 2005/5/15

Y1 - 2005/5/15

N2 - Magnetic nanoparticles coated with biochemical ligands are enabling many biological and medical applications. In particular biomagnetic sensors have potential advantages of simplicity and rapidity. We demonstrate a substrate-free biomagnetic sensing approach using the magnetic ac susceptibility of ferromagnetic particles suspended in a liquid. The magnetic relaxation of these particles is mainly due to Brownian rotational diffusion, which can be modified by binding the particles to the intended target. This scheme has several advantages: (i) it requires only one binding event; (ii) there is an inherent check of integrity; and (iii) the signal contains additional information about the target size.

AB - Magnetic nanoparticles coated with biochemical ligands are enabling many biological and medical applications. In particular biomagnetic sensors have potential advantages of simplicity and rapidity. We demonstrate a substrate-free biomagnetic sensing approach using the magnetic ac susceptibility of ferromagnetic particles suspended in a liquid. The magnetic relaxation of these particles is mainly due to Brownian rotational diffusion, which can be modified by binding the particles to the intended target. This scheme has several advantages: (i) it requires only one binding event; (ii) there is an inherent check of integrity; and (iii) the signal contains additional information about the target size.

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Biological sensing with magnetic nanoparticles using Brownian relaxation (invited)

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