Biological mechanism for the toxicity of haloacetic acid drinking water disinfection byproducts

Justin A. Pals, Justin K. Ang, Elizabeth D. Wagner, Michael J. Plewa

Research output: Contribution to journalArticle

Abstract

The halogenated acetic acids are a major class of drinking water disinfection byproducts (DBPs) with five haloacetic acids regulated by the U.S. EPA. These agents are cytotoxic, genotoxic, mutagenic, and teratogenic. The decreasing toxicity rank order of the monohalogenated acetic acids (monoHAAs) is iodo- > bromo- ≫ chloroacetic acid. We present data that the monoHAAs inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity in a concentration-dependent manner with the same rank order as above. The rate of inhibition of GAPDH and the toxic potency of the monoHAAs are highly correlated with their alkylating potential and the propensity of the halogen leaving group. This strong association between GAPDH inhibition and the monoHAA toxic potency supports a comprehensive mechanism for the adverse biological effects by this widely occurring class of regulated DBPs.

Original languageEnglish (US)
Pages (from-to)5791-5797
Number of pages7
JournalEnvironmental Science and Technology
Volume45
Issue number13
DOIs
StatePublished - Jul 1 2011

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry

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