Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products

Keyphrases

• Natural Products 100%
• Antibiotics 100%
• Bioinformatics 100%
• Bioinformatics Analysis 100%
• Biological Characterization 100%
• Bafilomycin A1 100%
• Actinobacteria 100%
• Biological Activity 50%
• Mode of Action 50%
• Stereochemistry 50%
• Bioactivity 50%
• NMR Analysis 50%
• Streptomyces 50%
• Bacillus Subtilis (B. subtilis) 50%
• Biosynthetic Gene Clusters 50%
• MS-MS 50%
• Antimicrobial Activity 50%
• Liquid Chromatography-high Resolution Mass Spectrometry (LC-HRMS) 50%
• Fumarate 50%
• Nucleophilic 1,4-addition 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Natural Product 100%
• Actinobacteria 100%
• Bafilomycin 100%
• Biological Activity 50%
• Streptomyces 50%
• Fumaric Acid 50%
• Antimicrobial Agent 50%

Chemistry

• Natural Product 100%
• NMR Spectroscopy 50%
• Bioactivity 50%
• Stereochemistry 50%
• Tandem Mass Spectrometry 50%
• Antimicrobial Agent 50%
• High Resolution Mass Spectrometry (HRMS) 50%