Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007)

V. J. Coyle, K. M. Rassnick, L. B. Borst, C. O. Rodriguez, N. C. Northrup, Timothy M Fan, Laura Diane Garrett

Research output: Contribution to journalArticle

Abstract

The purpose of this retrospective study was to describe the biological behaviour of canine mandibular osteosarcoma (OSA) and to examine factors for their impact on metastasis-free interval (MFI) and survival time (ST). Records from dogs treated with mandibulectomy for OSA (1999-2007) were reviewed. Archived tumour samples were evaluated for mitotic index (MI) and tumour grade. Fifty dogs were included, 21 received chemotherapy. Twenty-nine dogs (58%) developed metastatic disease. The median MFI was 627 days, and median ST was 525 days. In univariate analysis MI > 40 was prognostic for decreased MFI and ST. Grade also influenced MFI and ST, with 5/21 (24%) dogs with grade II/III tumours metastasis-free at one year versus 16/22 (72%) dogs with grade I tumours (P = 0.002); and 5/21 (24%) dogs with grade II/III tumours alive versus 17/22 (77%) dogs with grade I tumours (P = 0.001). In multivariate analysis, histological grade and adjuvant chemotherapy were prognostic for MFI and ST.

Original languageEnglish (US)
Pages (from-to)89-97
Number of pages9
JournalVeterinary and comparative oncology
Volume13
Issue number2
DOIs
StatePublished - Jun 1 2015

Fingerprint

osteosarcoma
Osteosarcoma
retrospective studies
Canidae
Retrospective Studies
metastasis
Dogs
Neoplasm Metastasis
dogs
neoplasms
Neoplasms
Mitotic Index
drug therapy
Adjuvant Chemotherapy
multivariate analysis
adjuvants
Multivariate Analysis
Drug Therapy

Keywords

  • Chemotherapy
  • Grade
  • Jaw
  • Mitotic index
  • Oral tumour

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007). / Coyle, V. J.; Rassnick, K. M.; Borst, L. B.; Rodriguez, C. O.; Northrup, N. C.; Fan, Timothy M; Garrett, Laura Diane.

In: Veterinary and comparative oncology, Vol. 13, No. 2, 01.06.2015, p. 89-97.

Research output: Contribution to journalArticle

Coyle, V. J. ; Rassnick, K. M. ; Borst, L. B. ; Rodriguez, C. O. ; Northrup, N. C. ; Fan, Timothy M ; Garrett, Laura Diane. / Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007). In: Veterinary and comparative oncology. 2015 ; Vol. 13, No. 2. pp. 89-97.
@article{13f32dcad55a4ed6b77c875f5480fca4,
title = "Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007)",
abstract = "The purpose of this retrospective study was to describe the biological behaviour of canine mandibular osteosarcoma (OSA) and to examine factors for their impact on metastasis-free interval (MFI) and survival time (ST). Records from dogs treated with mandibulectomy for OSA (1999-2007) were reviewed. Archived tumour samples were evaluated for mitotic index (MI) and tumour grade. Fifty dogs were included, 21 received chemotherapy. Twenty-nine dogs (58{\%}) developed metastatic disease. The median MFI was 627 days, and median ST was 525 days. In univariate analysis MI > 40 was prognostic for decreased MFI and ST. Grade also influenced MFI and ST, with 5/21 (24{\%}) dogs with grade II/III tumours metastasis-free at one year versus 16/22 (72{\%}) dogs with grade I tumours (P = 0.002); and 5/21 (24{\%}) dogs with grade II/III tumours alive versus 17/22 (77{\%}) dogs with grade I tumours (P = 0.001). In multivariate analysis, histological grade and adjuvant chemotherapy were prognostic for MFI and ST.",
keywords = "Chemotherapy, Grade, Jaw, Mitotic index, Oral tumour",
author = "Coyle, {V. J.} and Rassnick, {K. M.} and Borst, {L. B.} and Rodriguez, {C. O.} and Northrup, {N. C.} and Fan, {Timothy M} and Garrett, {Laura Diane}",
year = "2015",
month = "6",
day = "1",
doi = "10.1111/vco.12020",
language = "English (US)",
volume = "13",
pages = "89--97",
journal = "Veterinary and Comparative Oncology",
issn = "1476-5829",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007)

AU - Coyle, V. J.

AU - Rassnick, K. M.

AU - Borst, L. B.

AU - Rodriguez, C. O.

AU - Northrup, N. C.

AU - Fan, Timothy M

AU - Garrett, Laura Diane

PY - 2015/6/1

Y1 - 2015/6/1

N2 - The purpose of this retrospective study was to describe the biological behaviour of canine mandibular osteosarcoma (OSA) and to examine factors for their impact on metastasis-free interval (MFI) and survival time (ST). Records from dogs treated with mandibulectomy for OSA (1999-2007) were reviewed. Archived tumour samples were evaluated for mitotic index (MI) and tumour grade. Fifty dogs were included, 21 received chemotherapy. Twenty-nine dogs (58%) developed metastatic disease. The median MFI was 627 days, and median ST was 525 days. In univariate analysis MI > 40 was prognostic for decreased MFI and ST. Grade also influenced MFI and ST, with 5/21 (24%) dogs with grade II/III tumours metastasis-free at one year versus 16/22 (72%) dogs with grade I tumours (P = 0.002); and 5/21 (24%) dogs with grade II/III tumours alive versus 17/22 (77%) dogs with grade I tumours (P = 0.001). In multivariate analysis, histological grade and adjuvant chemotherapy were prognostic for MFI and ST.

AB - The purpose of this retrospective study was to describe the biological behaviour of canine mandibular osteosarcoma (OSA) and to examine factors for their impact on metastasis-free interval (MFI) and survival time (ST). Records from dogs treated with mandibulectomy for OSA (1999-2007) were reviewed. Archived tumour samples were evaluated for mitotic index (MI) and tumour grade. Fifty dogs were included, 21 received chemotherapy. Twenty-nine dogs (58%) developed metastatic disease. The median MFI was 627 days, and median ST was 525 days. In univariate analysis MI > 40 was prognostic for decreased MFI and ST. Grade also influenced MFI and ST, with 5/21 (24%) dogs with grade II/III tumours metastasis-free at one year versus 16/22 (72%) dogs with grade I tumours (P = 0.002); and 5/21 (24%) dogs with grade II/III tumours alive versus 17/22 (77%) dogs with grade I tumours (P = 0.001). In multivariate analysis, histological grade and adjuvant chemotherapy were prognostic for MFI and ST.

KW - Chemotherapy

KW - Grade

KW - Jaw

KW - Mitotic index

KW - Oral tumour

UR - http://www.scopus.com/inward/record.url?scp=84929289574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929289574&partnerID=8YFLogxK

U2 - 10.1111/vco.12020

DO - 10.1111/vco.12020

M3 - Article

C2 - 23410097

AN - SCOPUS:84929289574

VL - 13

SP - 89

EP - 97

JO - Veterinary and Comparative Oncology

JF - Veterinary and Comparative Oncology

SN - 1476-5829

IS - 2

ER -