Biological behavior of oral and perioral mast cell tumors in dogs: 44 cases (1996-2006)

Lorin A. Hillman, Laura Diane Garrett, Louis Philippe De Lorimier, Sarah C. Charney, Luke B. Borst, Timothy M Fan

Research output: Contribution to journalArticle

Abstract

Objective:-To describe clinical outcome of dogs with mast cell tumors (MCTs) arising from the oral mucosa, oral mucocutaneous junction, or perioral region of the muzzle and evaluate the potential role of the chemokine receptor type 7 (CCR7) in the biological behavior of these tumors. Design:-Retrospective case series. Animals:-44 dogs with MCTs of the oral mucosa (n = 14), oral mucocutaneous junction (19), or perioral region of the muzzle (11). Procedures:-Medical records were reviewed for information on signalment, regional metastasis, treatments, cause of death, and survival time. Twenty of the 44 cases had stored histologic samples available for immunohistochemical staining for CCR7. Results:-For all dogs, median survival time was 52 months. Twenty-six (59%) dogs had regional lymph node metastasis on admission. Median survival time for dogs with lymph node metastasis was 14 months, whereas median survival time was not reached for dogs without lymph node metastasis. Intensity of staining for CCR7 was not significantly associated with the presence of regional lymph node metastasis or survival time. Conclusions and Clinical Relevance:-Results suggested that in dogs with MCTs arising from the oral mucosa, oral mucocutaneous junction, or perioral region of the muzzle, the presence of regional lymph node metastasis at the time of diagnosis was a negative prognostic factor. However, prolonged survival times could be achieved with treatment. In addition, CCR7 expression in the primary tumor was not significantly associated with the presence of regional lymph node metastasis or survival time.

Original languageEnglish (US)
Pages (from-to)936-942
Number of pages7
JournalJournal of the American Veterinary Medical Association
Volume237
Issue number8
DOIs
StatePublished - Oct 15 2010

ASJC Scopus subject areas

  • veterinary(all)

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