Biological approaches to aphasia treatment

Steven L. Small, Daniel A. Llano

Research output: Contribution to journalReview article

Abstract

In this review, we discuss the basic mechanisms of neural regeneration and repair and attempt to correlate findings from animal models of stroke recovery with clinical trials for aphasia. Several randomized controlled clinical trials involving manipulation of different neurotransmitter systems, including noradrenergic, dopaminergic, cholinergic, and glutamatergic systems, have shown signals of efficacy. Biological approaches such as anti-Nogo and cell replacement therapy have shown efficacy in preclinical models but have yet to reach proof of concept in the clinic. Finally, noninvasive cortical stimulation techniques have been used in a few small trials and have shown promising results. It appears that the efficacy of all these platforms can be potentiated through coupling with concomitant behavioral intervention. Given this array of potential mechanisms that exist to augment and/or stimulate neural reorganization after stroke, we are optimistic that approaches to aphasia therapy will transition from compensatory models to models in which brain reorganization is the goal.

Original languageEnglish (US)
Pages (from-to)443-450
Number of pages8
JournalCurrent Neurology and Neuroscience Reports
Volume9
Issue number6
DOIs
StatePublished - Oct 26 2009

Fingerprint

Aphasia
Stroke
Cell- and Tissue-Based Therapy
Cholinergic Agents
Neurotransmitter Agents
Regeneration
Randomized Controlled Trials
Animal Models
Clinical Trials
Brain
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Biological approaches to aphasia treatment. / Small, Steven L.; Llano, Daniel A.

In: Current Neurology and Neuroscience Reports, Vol. 9, No. 6, 26.10.2009, p. 443-450.

Research output: Contribution to journalReview article

@article{141e9c7371f84585b69409dddeebf3d6,
title = "Biological approaches to aphasia treatment",
abstract = "In this review, we discuss the basic mechanisms of neural regeneration and repair and attempt to correlate findings from animal models of stroke recovery with clinical trials for aphasia. Several randomized controlled clinical trials involving manipulation of different neurotransmitter systems, including noradrenergic, dopaminergic, cholinergic, and glutamatergic systems, have shown signals of efficacy. Biological approaches such as anti-Nogo and cell replacement therapy have shown efficacy in preclinical models but have yet to reach proof of concept in the clinic. Finally, noninvasive cortical stimulation techniques have been used in a few small trials and have shown promising results. It appears that the efficacy of all these platforms can be potentiated through coupling with concomitant behavioral intervention. Given this array of potential mechanisms that exist to augment and/or stimulate neural reorganization after stroke, we are optimistic that approaches to aphasia therapy will transition from compensatory models to models in which brain reorganization is the goal.",
author = "Small, {Steven L.} and Llano, {Daniel A.}",
year = "2009",
month = "10",
day = "26",
doi = "10.1007/s11910-009-0066-x",
language = "English (US)",
volume = "9",
pages = "443--450",
journal = "Current Neurology and Neuroscience Reports",
issn = "1528-4042",
publisher = "Current Medicine Group",
number = "6",

}

TY - JOUR

T1 - Biological approaches to aphasia treatment

AU - Small, Steven L.

AU - Llano, Daniel A.

PY - 2009/10/26

Y1 - 2009/10/26

N2 - In this review, we discuss the basic mechanisms of neural regeneration and repair and attempt to correlate findings from animal models of stroke recovery with clinical trials for aphasia. Several randomized controlled clinical trials involving manipulation of different neurotransmitter systems, including noradrenergic, dopaminergic, cholinergic, and glutamatergic systems, have shown signals of efficacy. Biological approaches such as anti-Nogo and cell replacement therapy have shown efficacy in preclinical models but have yet to reach proof of concept in the clinic. Finally, noninvasive cortical stimulation techniques have been used in a few small trials and have shown promising results. It appears that the efficacy of all these platforms can be potentiated through coupling with concomitant behavioral intervention. Given this array of potential mechanisms that exist to augment and/or stimulate neural reorganization after stroke, we are optimistic that approaches to aphasia therapy will transition from compensatory models to models in which brain reorganization is the goal.

AB - In this review, we discuss the basic mechanisms of neural regeneration and repair and attempt to correlate findings from animal models of stroke recovery with clinical trials for aphasia. Several randomized controlled clinical trials involving manipulation of different neurotransmitter systems, including noradrenergic, dopaminergic, cholinergic, and glutamatergic systems, have shown signals of efficacy. Biological approaches such as anti-Nogo and cell replacement therapy have shown efficacy in preclinical models but have yet to reach proof of concept in the clinic. Finally, noninvasive cortical stimulation techniques have been used in a few small trials and have shown promising results. It appears that the efficacy of all these platforms can be potentiated through coupling with concomitant behavioral intervention. Given this array of potential mechanisms that exist to augment and/or stimulate neural reorganization after stroke, we are optimistic that approaches to aphasia therapy will transition from compensatory models to models in which brain reorganization is the goal.

UR - http://www.scopus.com/inward/record.url?scp=70350169896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350169896&partnerID=8YFLogxK

U2 - 10.1007/s11910-009-0066-x

DO - 10.1007/s11910-009-0066-x

M3 - Review article

C2 - 19818231

AN - SCOPUS:70350169896

VL - 9

SP - 443

EP - 450

JO - Current Neurology and Neuroscience Reports

JF - Current Neurology and Neuroscience Reports

SN - 1528-4042

IS - 6

ER -