Biological activities of 'noninfectious' influenza A virus particles

Research output: Contribution to journalReview articlepeer-review


Only a small fraction of influenza A virus (IAV) particles within a viral population register as infectious by traditional infectivity assays. Despite constituting the most abundant product of influenza infection, the role that the 'noninfectious' particle fraction plays in the biology of the virus has largely been ignored. This review shines a light on this oft-ignored population by highlighting studies, both old and new, that describe the unique biological activities of these particles, and discussing what this population can tell us about the biology of IAV evolution and disease.

Original languageEnglish (US)
Pages (from-to)41-51
Number of pages11
JournalFuture Virology
Issue number1
StatePublished - Jan 2014
Externally publishedYes


  • DI particles
  • aggregation
  • genome packaging
  • influenza
  • noninfectious
  • semi-infectious
  • virion heterogeneity
  • virus

ASJC Scopus subject areas

  • Virology


Dive into the research topics of 'Biological activities of 'noninfectious' influenza A virus particles'. Together they form a unique fingerprint.

Cite this