Biological activities of 'noninfectious' influenza A virus particles

Research output: Contribution to journalReview articlepeer-review

Abstract

Only a small fraction of influenza A virus (IAV) particles within a viral population register as infectious by traditional infectivity assays. Despite constituting the most abundant product of influenza infection, the role that the 'noninfectious' particle fraction plays in the biology of the virus has largely been ignored. This review shines a light on this oft-ignored population by highlighting studies, both old and new, that describe the unique biological activities of these particles, and discussing what this population can tell us about the biology of IAV evolution and disease.

Original languageEnglish (US)
Pages (from-to)41-51
Number of pages11
JournalFuture Virology
Volume9
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • DI particles
  • aggregation
  • genome packaging
  • influenza
  • noninfectious
  • semi-infectious
  • virion heterogeneity
  • virus

ASJC Scopus subject areas

  • Virology

Fingerprint Dive into the research topics of 'Biological activities of 'noninfectious' influenza A virus particles'. Together they form a unique fingerprint.

Cite this