The total synthesis of hirsutellones A (1), B (2), and C (3) has been achieved through a bioinspired late-stage sequence starting from advanced intermediate 6. The sequence proceeded via labile intermediate 17,1′-dehydrohirsutellone B (5) and delivered, in addition to the natural products (1-3), hirsutellone analogue 1′,2′,17-epi-hirsutellone C (1′,2′,17-epi-3).
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry