Bioinspired synthesis of hirsutellones A, B, and C

K. C. Nicolaou, Ya Ping Sun, David Sarlah, Weiqiang Zhan, T. Robert Wu

Research output: Contribution to journalArticlepeer-review


The total synthesis of hirsutellones A (1), B (2), and C (3) has been achieved through a bioinspired late-stage sequence starting from advanced intermediate 6. The sequence proceeded via labile intermediate 17,1′-dehydrohirsutellone B (5) and delivered, in addition to the natural products (1-3), hirsutellone analogue 1′,2′,17-epi-hirsutellone C (1′,2′,17-epi-3).

Original languageEnglish (US)
Pages (from-to)5708-5710
Number of pages3
JournalOrganic Letters
Issue number20
StatePublished - Oct 21 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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