Bioinformatics-guided discovery of biaryl-linked lasso peptides

Keyphrases

• Bioinformatics 100%
• Biaryls 100%
• Lasso Peptide 100%
• Guided Discovery 100%
• Biosynthetic Gene Clusters 33%
• RiPPs 33%
• Mass Spectrometry 16%
• Bacterial Cells 16%
• Bicyclol 16%
• Structural Characterization 16%
• Trivalent 16%
• Human Cells 16%
• Bioactivity 16%
• Cytochrome P450 Enzymes 16%
• Modified Peptide 16%
• P450 Enzymes 16%
• Sulfonium 16%
• Growth Suppression 16%
• Stable Isotopes 16%
• Isopeptide Bond 16%
• LARIAT 16%
• Genome Mining 16%
• 2D NMR 16%
• Ribosomally Synthesized 16%
• NMR Spectrometry 16%
• Isotope Incorporation 16%
• Peptide Scaffold 16%
• Micrococcus Luteus 16%
• Secondary Modification 16%
• Nocardia Terpenica 16%
• S-methylation 16%

Biochemistry, Genetics and Molecular Biology

• Gene Cluster 100%
• Mass Spectrometry 50%
• Gene Linkage 50%
• Enzyme 50%
• Cross-Link 50%
• Biological Activity 50%
• Methylation 50%
• Cytochrome P450 50%
• Growth Inhibition 50%
• Isopeptide Bond 50%
• Sulfonium 50%
• Nocardia 50%
• Micrococcus luteus 50%

Chemistry

• Biaryl 100%
• Structure 50%
• Mass Spectrometry 50%
• Methylation 50%
• Bioactivity 50%
• Cytochrome P450 50%
• Sulfonium 50%
• Stable Isotope 50%
• Two-Dimensional NMR 50%