Bioencapsulation of metronidazole in adult brine shrimp (Artemia sp.)

Matthew C. Allender, Mike Kastura, Robert George, Frank Bulman, Jason Yarbrough, Sherry Cox

Research output: Contribution to journalArticlepeer-review


A description of bioencapsulation of metronidazole in adult brine shrimp (Artemia) for 2.5 g/L, 5 g/L, and 10 g/L treatment baths is presented. Metronidazole was detected in adult brine shrimp tissue after enrichment periods of 15 min, 30 min, 1 hr, 2 hr, 4 hr, 8 hr, 12 hr, and 24 hr. The assays were performed using high performance liquid chromatography. There was a positive relationship in both dose and time. When evaluating percent uptake, all three baths demonstrated a similar pattern. All three bath concentrations had a high initial concentration that fell at 30 min and slowly began to increase through the end of the study. Survival of shrimp was not affected by bath concentration but decreased over time in all treatment baths comparatively. It can be concluded that metronidazole can be successfully bioencapsulated in adult Artemia.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalJournal of Zoo and Wildlife Medicine
Issue number2
StatePublished - Jun 2011
Externally publishedYes


  • Artemia
  • bioencapsulation
  • brine shrimp
  • metronidazole
  • pharmacology

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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