Bioelasticity imaging II: Spatial resolution

Larry T. Cook, Yanning Zhu, Timothy J. Hall, Michael F. Insana

Research output: Contribution to journalConference articlepeer-review


The large elasticity contrast possible with strain imaging promises new diagnostic information to augment x-ray, MRI, and ultrasound for the detection of tumors in soft tissue. In the past, we described the design of an elastographic system using the Fourier crosstalk concept introduced by Barrett and Gifford. The diagonal of the crosstalk matrix is related to the pre-sampled modulation transfer function (MTF) of the strain image. Another approach to measuring the spatial resolution of an elasticity image employs a linear frequency-modulated (chirp) strain pattern imposed upon a simulated ultrasonic echo field to study the strain modulation over a range of spatial frequencies in the image. In experiments, high contrast inclusions positioned at varying separations were imaged to apply the Rayleigh criterion for resolution measurement. We measured MTF curves that fell to 0.2 at a spatial frequency of 0.5 mm-1 to 1 mm-1 under realistic conditions. The spatial resolution for ultrasonic strain imaging strongly depends on the transducer properties and deformation patterns applied to the object. Experiments with tissue-like phantoms mimicking the properties of early breast cancer show that 2 mm spheres three times stiffer than the background can be readily resolved. Thus, the potential for using elasticity imaging to detect excellent.

Original languageEnglish (US)
Pages (from-to)315-324
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2000
Externally publishedYes
EventMedical Imaging 2000: Ultrasonic Imaging and Signal Processing - San Diego, CA, USA
Duration: Feb 16 2000Feb 17 2000

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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