Biodegradable MRI Visible Drug Eluting Stent Reinforced by Metal Organic Frameworks

Rezvani Alanagh Hamideh; Babak Akbari; Parinaz Fathi; Santosh K. Misra; Andre Sutrisno; Fan Lam; Dipanjan Pan

doi:10.1002/adhm.202000136

Biodegradable MRI Visible Drug Eluting Stent Reinforced by Metal Organic Frameworks

Rezvani Alanagh Hamideh, Babak Akbari, Parinaz Fathi, Santosh K. Misra, Andre Sutrisno, Fan Lam, Dipanjan Pan

Research output: Contribution to journal › Article › peer-review

Abstract

Metal–organic frameworks (MOFs) have applications in numerous fields. However, the development of MOF-based “theranostic” macroscale devices is not achieved. Here, heparin-coated biocompatible MOF/poly(ε-caprolactone) (PCL) “theranostic” stents are developed, where NH₂-Materials of Institute Lavoisier (MIL)-101(Fe) encapsulates and releases rapamycin (an immunosuppressive drug). These stents also act as a remarkable source of contrast in ex vivo magnetic resonance imaging (MRI) compared to the invisible polymeric stent. The in vitro release patterns of heparin and rapamycin respectively can ensure a type of programmed model to prevent blood coagulation immediately after stent placement in the artery and stenosis over a longer term. Due to the presence of hydrolysable functionalities in MOFs, the stents are shown to be highly biodegradable in degradation tests under various conditions. Furthermore, there is no compromise of mechanical strength or flexibility with MOF compositing. The system described here promises many biomedical applications in macroscale theranostic devices. The use of MOF@PCL can render a medical device MRI-visible while simultaneously acting as a carrier for therapeutic agents.

Original language	English (US)
Article number	2000136
Journal	Advanced Healthcare Materials
Volume	9
Issue number	14
DOIs	https://doi.org/10.1002/adhm.202000136
State	Published - Jul 1 2020

Keywords

MRI
biodegradable implants
drug eluting stents
metal organic frameworks
theranostics

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

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title = "Biodegradable MRI Visible Drug Eluting Stent Reinforced by Metal Organic Frameworks",

abstract = "Metal–organic frameworks (MOFs) have applications in numerous fields. However, the development of MOF-based “theranostic” macroscale devices is not achieved. Here, heparin-coated biocompatible MOF/poly(ε-caprolactone) (PCL) “theranostic” stents are developed, where NH2-Materials of Institute Lavoisier (MIL)-101(Fe) encapsulates and releases rapamycin (an immunosuppressive drug). These stents also act as a remarkable source of contrast in ex vivo magnetic resonance imaging (MRI) compared to the invisible polymeric stent. The in vitro release patterns of heparin and rapamycin respectively can ensure a type of programmed model to prevent blood coagulation immediately after stent placement in the artery and stenosis over a longer term. Due to the presence of hydrolysable functionalities in MOFs, the stents are shown to be highly biodegradable in degradation tests under various conditions. Furthermore, there is no compromise of mechanical strength or flexibility with MOF compositing. The system described here promises many biomedical applications in macroscale theranostic devices. The use of MOF@PCL can render a medical device MRI-visible while simultaneously acting as a carrier for therapeutic agents.",

keywords = "MRI, biodegradable implants, drug eluting stents, metal organic frameworks, theranostics",

author = "Hamideh, {Rezvani Alanagh} and Babak Akbari and Parinaz Fathi and Misra, {Santosh K.} and Andre Sutrisno and Fan Lam and Dipanjan Pan",

note = "Funding Information: This work was carried out in part in the Materials Research Laboratory Central Research Facilities, University of Illinois. The authors gratefully acknowledge Dr. Jessica Spear and Dr. Anu Ramakrishnan from University of Illinois at Urbana‐Champaign (UIUC) for their helpful comments. This work was supported by funding from the University of Illinois at Urbana‐Champaign, the National Institute of Biomedical Imaging and Bioengineering (NIBIB) R03 EB028026‐01, the Children's Discovery Institute, and the National Science Foundation. H.R.A. and B.A. gratefully acknowledge funding from Iranian Ministry of Science, Research and Technology and the University of Tehran. The authors thank Dr. Tor Jensen (Biomedical Research Center of Carle Foundation hospital) and Benjamin Peterson (Animal Sciences Department, UIUC) for their assistance in blood related experiments. Blood from pig arteries was collected by the UIUC Meat Laboratory (Animal Sciences Department, University of Illinois, Protocol number 17277 and 19267) and Carle hospital. ",

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doi = "10.1002/adhm.202000136",

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AU - Hamideh, Rezvani Alanagh

AU - Akbari, Babak

AU - Fathi, Parinaz

AU - Misra, Santosh K.

AU - Sutrisno, Andre

AU - Lam, Fan

AU - Pan, Dipanjan

N1 - Funding Information: This work was carried out in part in the Materials Research Laboratory Central Research Facilities, University of Illinois. The authors gratefully acknowledge Dr. Jessica Spear and Dr. Anu Ramakrishnan from University of Illinois at Urbana‐Champaign (UIUC) for their helpful comments. This work was supported by funding from the University of Illinois at Urbana‐Champaign, the National Institute of Biomedical Imaging and Bioengineering (NIBIB) R03 EB028026‐01, the Children's Discovery Institute, and the National Science Foundation. H.R.A. and B.A. gratefully acknowledge funding from Iranian Ministry of Science, Research and Technology and the University of Tehran. The authors thank Dr. Tor Jensen (Biomedical Research Center of Carle Foundation hospital) and Benjamin Peterson (Animal Sciences Department, UIUC) for their assistance in blood related experiments. Blood from pig arteries was collected by the UIUC Meat Laboratory (Animal Sciences Department, University of Illinois, Protocol number 17277 and 19267) and Carle hospital.

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