Biodegradable micelles capable of mannose-mediated targeted drug delivery to cancer cells

Lichen Yin, Yongbing Chen, Zhonghai Zhang, Qian Yin, Nan Zheng, Jianjun Cheng

Research output: Contribution to journalArticlepeer-review

Abstract

A targeted micellar drug delivery system is developed from a biocompatible and biodegradable amphiphilic polyester, poly(Lac-OCA)-b-(poly(Tyr(alkynyl)-OCA)-g-mannose) (PLA-b-(PTA-g-mannose), that is synthesized via controlled ring-opening polymerization of O-carboxyanhydride (OCA) and highly efficient "Click" chemistry. Doxorubicin (DOX), a model lipophilic anticancer drug, can be effectively encapsulated into the micelles, and the mannose moiety allows active targeting of the micelles to cancer cells that specifically express mannose receptors, which thereafter enhances the anticancer efficiency of the drug. Comprised entirely of biodegradable and biocompatible polyesters, this micellar system demonstrates promising potentials for targeted drug delivery and cancer therapy.

Original languageEnglish (US)
Pages (from-to)483-489
Number of pages7
JournalMacromolecular Rapid Communications
Volume36
Issue number5
DOIs
StatePublished - Mar 1 2015

Keywords

  • Micelles
  • O-carbyxyanhydride
  • Polyesters
  • Ring-opening polymerization
  • Targeted drug delivery

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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