@article{5a7703d1c1694632b2622637aeb4ee86,
title = "Biodegradable metal-derived magnesium and sodium enhances bone regeneration by angiogenesis aided osteogenesis and regulated biological apatite formation",
abstract = "Biodegradable metals have great attraction to become orthopaedic implants. Here, we demonstrated a biodegradable magnesium alloy incorporated with essential element sodium through Sn-Na master alloying technique. The designed MgSnZnNa alloy presented better hardness and corrosion resistance due to the uniform distribution of Na in Mg2Sn second phase and solid soluble Zn in Mg matrix. The co-release of Mg and Na ions resulted in advanced upregulation of osterix and osteocalcin expression in adipose derived stem cells in vitro. It significantly promoted the rat calvarial defect bone regeneration through osteogenesis and angiogenesis, attributed to the co-release of Na and Mg ions, by increasing the expression of calcitonin gene-related peptide, osteocalcin as well as vascular endothelial growth factor. The current study provided an innovative approach by using master alloy to incorporate essential elements (such as Na or K) for fabricating biodegradable Mg alloys with reduced galvanic corrosion and enhanced biological functions.",
keywords = "Biodegradable metals, Calvarial defect, Magnesium alloy, Osteogenesis, Sodium",
author = "Yang Liu and Huafang Li and Jiankun Xu and Jessica TerBush and Wenting Li and Mohan Setty and Shaokang Guan and Nguyen, {Thanh D.} and Ling Qin and Yufeng Zheng",
note = "Funding Information: We thank Prof. Matthew Barnett and Dr. Aiden Beer from Deakin University for the help in material preparation, and Ms Junyu Guo from University College London for the help on grammar, word use, and punctuation. This work was supported by National Natural Science Foundation of China , China [Grants No. 51871004 , 31700819 and 81802152 ], NSFC/RGC Joint Research Scheme [Grant No. 5161101031 ], the Young Elite Scientists Sponsorship Program by CAST [YESS, Grant No. 2018QNRC001 ] and the Fundamental Research Funds for the Central Universities , China [Grant No. 06500098 ], the Hong Kong RGC Theme-based Research Scheme [Ref No. T13-402/17-N ], RGC Collaborative Research Fund [Ref No. C4026-17WF ]. Funding Information: We thank Prof. Matthew Barnett and Dr. Aiden Beer from Deakin University for the help in material preparation, and Ms Junyu Guo from University College London for the help on grammar, word use, and punctuation. This work was supported by National Natural Science Foundation of China, China [Grants No. 51871004, 31700819 and 81802152], NSFC/RGC Joint Research Scheme [Grant No. 5161101031], the Young Elite Scientists Sponsorship Program by CAST [YESS, Grant No. 2018QNRC001] and the Fundamental Research Funds for the Central Universities, China [Grant No. 06500098], the Hong Kong RGC Theme-based Research Scheme [Ref No. T13-402/17-N], RGC Collaborative Research Fund [Ref No. C4026-17WF]. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",
year = "2021",
month = apr,
day = "15",
doi = "10.1016/j.cej.2020.127616",
language = "English (US)",
volume = "410",
journal = "Chemical Engineering Journal",
issn = "1385-8947",
publisher = "Elsevier",
}