Biochemistry and immune biomarkers indicate interacting effects of pre-and postnatal stressors in pigs across sexes

Haley E. Rymut, Laurie A. Rund, Courtni R. Bolt, Maria Bonita Villamil, Diane E. Bender, Bruce R. Southey, Rodney W. Johnson, Sandra L. Rodriguez-Zas

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of maternal immune activation (MIA) elicited by a prenatal stressor and postnatal metabolic or immune stressors on chemical and inflammatory biomarkers were studied in male and female pigs. Pigs exposed to MIA elicited by porcine reproductive and respiratory syndrome virus and matching controls were assigned at two months of age to fasting stress, immune stress, or a saline group. The serum levels of over 30 chemistry and immune analytes were studied. Significantly low levels of blood urea nitrogen were detected in females exposed to MIA, while the highest creatinine levels were identified in fasting females exposed to MIA. The levels of interferon gamma and interleukin 8 were highest in pigs exposed to postnatal immune challenge. The profiles suggest that MIA may sensitize pigs to postnatal stressors for some indicators while making them more tolerant of other stressors. Effectiveness of practices to ameliorate the impact of postnatal stressors on the physiology of the pig could be enhanced by considering the prenatal stress circumstances.

Original languageEnglish (US)
Article number987
JournalAnimals
Volume11
Issue number4
DOIs
StatePublished - Apr 2021

Keywords

  • Biomarkers
  • Cytokines
  • Fasting
  • Maternal immune activation
  • Poly(I:C)

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Fingerprint Dive into the research topics of 'Biochemistry and immune biomarkers indicate interacting effects of pre-and postnatal stressors in pigs across sexes'. Together they form a unique fingerprint.

Cite this