@article{13af8894c0e44fe48c6d60703fbc71ca,
title = "Biochemical and biophysical understanding of metal ion selectivity of DNAzymes",
abstract = "This review summarizes research on the metal-binding properties of catalytic DNAzymes, towards the goal of understanding the structural properties leading to metal ion specificity. Progress made and insight gained from a range of biochemical and biophysical techniques are covered, and promising directions for future investigations are discussed.",
keywords = "Catalytic DNA, Deoxyribozymes, Metal ion selectivity, Metal sensors, Metalloenzymes, Metal–nucleic acid interactions",
author = "Kevin Hwang and Parisa Hosseinzadeh and Yi Lu",
note = "The Lu group research mentioned in this review has been supported by the U.S. National Institutes of Health (Grant ES016865), by the Office of Science (BER), the U.S. Department of Energy ( DE-FG02-08ER64568 ), and National Science Foundation ( CTS-0120978 , CMMI 0749028 and DMR-0117792 ). Yi Lu received his BS degree from Peking University in 1986, and a PhD degree from University of California at Los Angeles in 1992 under Professor Joan S. Valentine. After 2 years of postdoctoral research in Professor Harry B. Gray{\textquoteright}s group at the California Institute of Technology, Lu started his own independent career in the Department of Chemistry at the University of Illinois at Urbana Champaign in 1994. He is now a Jay and Ann Schenck Professor of Chemistry and a HHMI Professor in the Departments of Chemistry, Biochemistry, Bioengineering and Materials Science and Engineering. He is also a member of the Center for Biophysics and Computational Biology and Beckman Institute for Advanced Science and Technology. His research interests lie at the interface between chemistry and biology. His group is developing new chemical approaches to provide deeper insight into biological systems. At the same time, they take advantage of recently developed biological tools to advance many areas in chemistry. Lu has received numerous research and teaching awards, including the Royal Society of Chemistry Applied Inorganic Chemistry Award (2015), Fellow of the Royal Society of Chemistry (2015), Fellow of the American Association for the Advancement of Science (2007), Early Career Award, Society of Biological Inorganic Chemistry (2007), Howard Hughes Medical Institute Professor Award (2002), Camille Dreyfus Teacher-Scholar Award (1999), Alfred P. Sloan Research Fellowship (1998), Research Corporation Cottrell Scholars Award (1997), and the Beckman Young Investigators Award (1996).",
year = "2016",
doi = "10.1016/j.ica.2016.04.017",
language = "English (US)",
volume = "452",
pages = "12--24",
journal = "Inorganica Chimica Acta",
issn = "0020-1693",
publisher = "Elsevier B.V.",
}