Biochemical and biophysical understanding of metal ion selectivity of DNAzymes

Kevin Hwang, Parisa Hosseinzadeh, Yi Lu

Research output: Contribution to journalReview article


This review summarizes research on the metal-binding properties of catalytic DNAzymes, towards the goal of understanding the structural properties leading to metal ion specificity. Progress made and insight gained from a range of biochemical and biophysical techniques are covered, and promising directions for future investigations are discussed.

Original languageEnglish (US)
Pages (from-to)12-24
Number of pages13
JournalInorganica Chimica Acta
StatePublished - Jan 1 2016


  • Catalytic DNA
  • Deoxyribozymes
  • Metal ion selectivity
  • Metal sensors
  • Metalloenzymes
  • Metal–nucleic acid interactions

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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