Abstract
Biocatalysis has been increasingly used for pharmaceutical synthesis in an effort to make manufacturing processes greener and more sustainable. Biocatalysts that possess excellent activity, specificity, thermostability and solvent-tolerance are highly sought after to meet the requirements of practical applications. Generating biocatalysts with these specific properties can be achieved by either discovery of novel biocatalysts or protein engineering. Meanwhile, chemoenzymatic routes have also been designed and developed for pharmaceutical synthesis on an industrial scale. This review discusses the recent discoveries, engineering, and applications of biocatalysts for the synthesis of pharmaceuticals and pharmaceutical intermediates. Key classes of biocatalysts include reductases, oxidases, hydrolases, lyases, isomerases, and transaminases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1275-1284 |
| Number of pages | 10 |
| Journal | Bioorganic and Medicinal Chemistry |
| Volume | 26 |
| Issue number | 7 |
| DOIs | |
| State | Published - Apr 1 2018 |
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Keywords
- Biocatalysis
- Hydrolases
- Isomerases
- Lyases
- Oxidases
- Pharmaceutical intermediates
- Pharmaceuticals
- Reductases
- Transaminases
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
Cite this
Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates. / Sun, Huihua; Zhang, Hongfang; Ang, Ee Lui; Zhao, Huimin.
In: Bioorganic and Medicinal Chemistry, Vol. 26, No. 7, 01.04.2018, p. 1275-1284.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates
AU - Sun, Huihua
AU - Zhang, Hongfang
AU - Ang, Ee Lui
AU - Zhao, Huimin
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Biocatalysis has been increasingly used for pharmaceutical synthesis in an effort to make manufacturing processes greener and more sustainable. Biocatalysts that possess excellent activity, specificity, thermostability and solvent-tolerance are highly sought after to meet the requirements of practical applications. Generating biocatalysts with these specific properties can be achieved by either discovery of novel biocatalysts or protein engineering. Meanwhile, chemoenzymatic routes have also been designed and developed for pharmaceutical synthesis on an industrial scale. This review discusses the recent discoveries, engineering, and applications of biocatalysts for the synthesis of pharmaceuticals and pharmaceutical intermediates. Key classes of biocatalysts include reductases, oxidases, hydrolases, lyases, isomerases, and transaminases.
AB - Biocatalysis has been increasingly used for pharmaceutical synthesis in an effort to make manufacturing processes greener and more sustainable. Biocatalysts that possess excellent activity, specificity, thermostability and solvent-tolerance are highly sought after to meet the requirements of practical applications. Generating biocatalysts with these specific properties can be achieved by either discovery of novel biocatalysts or protein engineering. Meanwhile, chemoenzymatic routes have also been designed and developed for pharmaceutical synthesis on an industrial scale. This review discusses the recent discoveries, engineering, and applications of biocatalysts for the synthesis of pharmaceuticals and pharmaceutical intermediates. Key classes of biocatalysts include reductases, oxidases, hydrolases, lyases, isomerases, and transaminases.
KW - Biocatalysis
KW - Hydrolases
KW - Isomerases
KW - Lyases
KW - Oxidases
KW - Pharmaceutical intermediates
KW - Pharmaceuticals
KW - Reductases
KW - Transaminases
UR - http://www.scopus.com/inward/record.url?scp=85021919856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021919856&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2017.06.043
DO - 10.1016/j.bmc.2017.06.043
M3 - Review article
C2 - 28709846
AN - SCOPUS:85021919856
VL - 26
SP - 1275
EP - 1284
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
SN - 0968-0896
IS - 7
ER -