TY - GEN
T1 - Bioactive polyketides from a Penicillium lanosum strain derived from a swab of bat's wing
AU - Zhan, G.
AU - Jarrod, K.
AU - Miller, Andrew N.
AU - Cichewicz, R. H.
PY - 2015
Y1 - 2015
N2 - Bacterial infection, particularly from multi-drug resistant strains, remains a serious threat to human lives. Thus, there is a clear and critical medical need for the discovery of novel antibacterial agents. Our recent work within the scope of an anti-multidrug-resistant Acinetobacter baumannii screening program led to the isolation of one fungal strain Penicillium lanosum 1298 – 15 from a swab of bat's wing. Bioassay guided fractionation of the secondary metabolites from the strain 1298 – 15 afforded 4 new polyketide lanoctones A-D (1-4), along with 3 known compounds: 3-chloro-2,5- dihydroxybenzyl alcohol (5), sohirnone A (6) and bislongiquinolide (7). Compounds 5 and 6 exhibited strong activity with IC50 values of 5.7 nM and 45.4 nM. However, compounds 1-4 and 7 showed weak or no activity.
AB - Bacterial infection, particularly from multi-drug resistant strains, remains a serious threat to human lives. Thus, there is a clear and critical medical need for the discovery of novel antibacterial agents. Our recent work within the scope of an anti-multidrug-resistant Acinetobacter baumannii screening program led to the isolation of one fungal strain Penicillium lanosum 1298 – 15 from a swab of bat's wing. Bioassay guided fractionation of the secondary metabolites from the strain 1298 – 15 afforded 4 new polyketide lanoctones A-D (1-4), along with 3 known compounds: 3-chloro-2,5- dihydroxybenzyl alcohol (5), sohirnone A (6) and bislongiquinolide (7). Compounds 5 and 6 exhibited strong activity with IC50 values of 5.7 nM and 45.4 nM. However, compounds 1-4 and 7 showed weak or no activity.
KW - INHS
UR - http://dx.doi.org/10.1055/s-0035-1556202
U2 - 10.1055/s-0035-1556202
DO - 10.1055/s-0035-1556202
M3 - Conference contribution
VL - 81 (11)
SP - 880
EP - 880
BT - Planta Medica
ER -