Bacterial infection, particularly from multi-drug resistant strains, remains a serious threat to human lives. Thus, there is a clear and critical medical need for the discovery of novel antibacterial agents. Our recent work within the scope of an anti-multidrug-resistant Acinetobacter baumannii screening program led to the isolation of one fungal strain Penicillium lanosum 1298 – 15 from a swab of bat's wing. Bioassay guided fractionation of the secondary metabolites from the strain 1298 – 15 afforded 4 new polyketide lanoctones A-D (1-4), along with 3 known compounds: 3-chloro-2,5- dihydroxybenzyl alcohol (5), sohirnone A (6) and bislongiquinolide (7). Compounds 5 and 6 exhibited strong activity with IC50 values of 5.7 nM and 45.4 nM. However, compounds 1-4 and 7 showed weak or no activity.
|Original language||English (US)|
|Title of host publication||Planta Medica|
|State||Published - 2015|