Bioactive nutrients - Time for tolerable upper intake levels to address safety

Allison A. Yates, John W. Erdman, Andrew Shao, Laurie C. Dolan, James C. Griffiths

Research output: Contribution to journalArticlepeer-review


There is increasing interest by consumers, researchers, and regulators into the roles that certain bioactive compounds, derived from plants and other natural sources, can play in health maintenance and promotion, and even prolonging a productive quality of life. Research has rapidly emerged suggesting that a wide range of compounds and mixtures in and from plants (such as fruits and vegetables, tea and cocoa) and animals (such as fish and probiotics) may exert substantial health benefits. There is interest in exploring the possibility of establishing recommended intakes or dietary guidance for certain bioactive substances to help educate consumers. A key aspect of establishing dietary guidance is the assessment of safety/toxicity of these substances. Toxicologists need to be involved in both the development of the safety framework and in the evaluation of the science to establish maximum intake/upper limits.

Original languageEnglish (US)
Pages (from-to)94-101
Number of pages8
JournalRegulatory Toxicology and Pharmacology
StatePublished - Mar 1 2017


  • Bioactives
  • DRIs
  • Dietary reference intakes
  • EGCG
  • Epigallocatechin gallate
  • Green tea
  • Lutein
  • Nutrient reference values
  • Nutrition
  • Tolerable upper intake levels

ASJC Scopus subject areas

  • Toxicology


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