Bio-resorbable nanoceramics for gene and drug delivery

Waltraud M. Kriven, Seo Young Kwak, Matthew A. Wallig, Jin Ho Choy

Research output: Contribution to journalArticle

Abstract

Nanoscale ceramic particles, such as layered double hydroxides (LDHs), have been developed to deliver drugs or genes into biological cells. In this article, we describe the controlled-release properties of LDHs as drug delivery carriers, the formation of bio-LDH nanohybrids, their in vivo and in vitro cytotoxicity tests, and their potential as anticancer gene delivery carriers. Unstable biomolecules can be intercalated into LDHs, displacing the interlayer anions; the drug or gene's negative charge is thus shielded, enabling penetration into the cell. In the slightly acidic environment of the cell, ceramic nanoplatelets of ∼100 nm diameter dissolve, thus releasing the intercalates in a controlled manner.

Original languageEnglish (US)
Pages (from-to)33-37
Number of pages5
JournalMRS Bulletin
Volume29
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • Biomedical materials
  • Ceramics
  • Drug delivery
  • Intercalation
  • Nonviral vectors
  • Safety studies
  • Scanning electron microscopy (SEM)
  • Transmission electron microscopy (TEM)

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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