Bio-resorbable nanoceramics for gene and drug delivery

Waltraud M. Kriven, Seo Young Kwak, Matthew A. Wallig, Jin Ho Choy

Research output: Contribution to journalArticlepeer-review

Abstract

Nanoscale ceramic particles, such as layered double hydroxides (LDHs), have been developed to deliver drugs or genes into biological cells. In this article, we describe the controlled-release properties of LDHs as drug delivery carriers, the formation of bio-LDH nanohybrids, their in vivo and in vitro cytotoxicity tests, and their potential as anticancer gene delivery carriers. Unstable biomolecules can be intercalated into LDHs, displacing the interlayer anions; the drug or gene's negative charge is thus shielded, enabling penetration into the cell. In the slightly acidic environment of the cell, ceramic nanoplatelets of ∼100 nm diameter dissolve, thus releasing the intercalates in a controlled manner.

Original languageEnglish (US)
Pages (from-to)33-37
Number of pages5
JournalMRS Bulletin
Volume29
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • Biomedical materials
  • Ceramics
  • Drug delivery
  • Intercalation
  • Nonviral vectors
  • Safety studies
  • Scanning electron microscopy (SEM)
  • Transmission electron microscopy (TEM)

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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