Bio-inspired imager improves sensitivity in near-infrared fluorescence image-guided surgery

Missael Garcia, Christopher Edmiston, Timothy York, Radoslav Marinov, Suman Mondal, Nan Zhu, Gail P. Sudlow, Walter J. Akers, Julie Margenthaler, Samuel Achilefu, Rongguang Liang, Mohamed A. Zayed, Marta Y. Pepino, Viktor Gruev

Research output: Contribution to journalArticle

Abstract

Image-guided surgery can enhance cancer treatment by decreasing, and ideally eliminating, positive tumor margins and iatrogenic damage to healthy tissue. Current state-of-the-art near-infrared fluorescence imaging systems are bulky and costly, lack sensitivity under surgical illumination, and lack co-registration accuracy between multimodal images. As a result, an overwhelming majority of physicians still rely on their unaided eyes and palpation as the primary sensing modalities for distinguishing cancerous from healthy tissue. Here we introduce an innovative design, comprising an artificial multispectral sensor inspired by the Morpho butterfly’s compound eye, which can significantly improve image-guided surgery. By monolithically integrating spectral tapetal filters with photodetectors, we have realized a single-chip multispectral imager with 1000 × higher sensitivity and 7 × better spatial co-registration accuracy compared to clinical imaging systems in current use. Preclinical and clinical data demonstrate that this technology seamlessly integrates into the surgical workflow while providing surgeons with real-time information on the location of cancerous tissue and sentinel lymph nodes. Due to its low manufacturing cost, our bio-inspired sensor will provide resource-limited hospitals with much-needed technology to enable more accurate value-based health care.

Original languageEnglish (US)
Pages (from-to)413-422
Number of pages10
JournalOptica
Volume5
Issue number4
DOIs
StatePublished - Apr 20 2018

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Image sensors
surgery
Surgery
Fluorescence
Tissue
Infrared radiation
Imaging systems
fluorescence
sensitivity
surgeons
Oncology
physicians
lymphatic system
sensors
Sensors
Medical imaging
Photodetectors
Health care
health
photometers

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Bio-inspired imager improves sensitivity in near-infrared fluorescence image-guided surgery. / Garcia, Missael; Edmiston, Christopher; York, Timothy; Marinov, Radoslav; Mondal, Suman; Zhu, Nan; Sudlow, Gail P.; Akers, Walter J.; Margenthaler, Julie; Achilefu, Samuel; Liang, Rongguang; Zayed, Mohamed A.; Pepino, Marta Y.; Gruev, Viktor.

In: Optica, Vol. 5, No. 4, 20.04.2018, p. 413-422.

Research output: Contribution to journalArticle

Garcia, M, Edmiston, C, York, T, Marinov, R, Mondal, S, Zhu, N, Sudlow, GP, Akers, WJ, Margenthaler, J, Achilefu, S, Liang, R, Zayed, MA, Pepino, MY & Gruev, V 2018, 'Bio-inspired imager improves sensitivity in near-infrared fluorescence image-guided surgery', Optica, vol. 5, no. 4, pp. 413-422. https://doi.org/10.1364/OPTICA.5.000413
Garcia M, Edmiston C, York T, Marinov R, Mondal S, Zhu N et al. Bio-inspired imager improves sensitivity in near-infrared fluorescence image-guided surgery. Optica. 2018 Apr 20;5(4):413-422. https://doi.org/10.1364/OPTICA.5.000413
Garcia, Missael ; Edmiston, Christopher ; York, Timothy ; Marinov, Radoslav ; Mondal, Suman ; Zhu, Nan ; Sudlow, Gail P. ; Akers, Walter J. ; Margenthaler, Julie ; Achilefu, Samuel ; Liang, Rongguang ; Zayed, Mohamed A. ; Pepino, Marta Y. ; Gruev, Viktor. / Bio-inspired imager improves sensitivity in near-infrared fluorescence image-guided surgery. In: Optica. 2018 ; Vol. 5, No. 4. pp. 413-422.
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