Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care

Ha Uk Chung; Bong Hoon Kim; Jong Yoon Lee; Jungyup Lee; Zhaoqian Xie; Erin M. Ibler; Kun Hyuck Lee; Anthony Banks; Ji Yoon Jeong; Jongwon Kim; Christopher Ogle; Dominic Grande; Yongjoon Yu; Hokyung Jang; Pourya Assem; Dennis Ryu; Jean Won Kwak; Myeong Namkoong; Jun Bin Park; Yechan Lee; Do Hoon Kim; Arin Ryu; Jaeseok Jeong; Kevin You; Bowen Ji; Zhuangjian Liu; Qingze Huo; Xue Feng; Yujun Deng; Yeshou Xu; Kyung In Jang; Jeonghyun Kim; Yihui Zhang; Roozbeh Ghaffari; Casey M. Rand; Molly Schau; Aaron Hamvas; Debra E. Weese-Mayer; Yonggang Huang; Seung Min Lee; Chi Hwan Lee; Naresh R. Shanbhag; Amy S. Paller; Shuai Xu; John A. Rogers

doi:10.1126/science.aau0780

Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care

Ha Uk Chung, Bong Hoon Kim, Jong Yoon Lee, Jungyup Lee, Zhaoqian Xie, Erin M. Ibler, Kun Hyuck Lee, Anthony Banks, Ji Yoon Jeong, Jongwon Kim, Christopher Ogle, Dominic Grande, Yongjoon Yu, Hokyung Jang, Pourya Assem, Dennis Ryu, Jean Won Kwak, Myeong Namkoong, Jun Bin Park, Yechan LeeDo Hoon Kim, Arin Ryu, Jaeseok Jeong, Kevin You, Bowen Ji, Zhuangjian Liu, Qingze Huo, Xue Feng, Yujun Deng, Yeshou Xu, Kyung In Jang, Jeonghyun Kim, Yihui Zhang, Roozbeh Ghaffari, Casey M. Rand, Molly Schau, Aaron Hamvas, Debra E. Weese-Mayer, Yonggang Huang, Seung Min Lee, Chi Hwan Lee, Naresh R. Shanbhag, Amy S. Paller, Shuai Xu, John A. Rogers

Research output: Contribution to journal › Article › peer-review

Abstract

Existing vital sign monitoring systems in the neonatal intensive care unit (NICU) require multiple wires connected to rigid sensors with strongly adherent interfaces to the skin. We introduce a pair of ultrathin, soft, skin-like electronic devices whose coordinated, wireless operation reproduces the functionality of these traditional technologies but bypasses their intrinsic limitations. The enabling advances in engineering science include designs that support wireless, battery-free operation; real-time, in-sensor data analytics; time-synchronized, continuous data streaming; soft mechanics and gentle adhesive interfaces to the skin; and compatibility with visual inspection and with medical imaging techniques used in the NICU. Preliminary studies on neonates admitted to operating NICUs demonstrate performance comparable to the most advanced clinical-standard monitoring systems.

Original language	English (US)
Journal	Science
Volume	363
Issue number	6430
DOIs	https://doi.org/10.1126/science.aau0780
State	Published - 2019

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Chung, H. U., Kim, B. H., Lee, J. Y., Lee, J., Xie, Z., Ibler, E. M., Lee, K. H., Banks, A., Jeong, J. Y., Kim, J., Ogle, C., Grande, D., Yu, Y., Jang, H., Assem, P., Ryu, D., Kwak, J. W., Namkoong, M., Park, J. B., ... Rogers, J. A. (2019). Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care. Science, 363(6430). https://doi.org/10.1126/science.aau0780

Chung, HU, Kim, BH, Lee, JY, Lee, J, Xie, Z, Ibler, EM, Lee, KH, Banks, A, Jeong, JY, Kim, J, Ogle, C, Grande, D, Yu, Y, Jang, H, Assem, P, Ryu, D, Kwak, JW, Namkoong, M, Park, JB, Lee, Y, Kim, DH, Ryu, A, Jeong, J, You, K, Ji, B, Liu, Z, Huo, Q, Feng, X, Deng, Y, Xu, Y, Jang, KI, Kim, J, Zhang, Y, Ghaffari, R, Rand, CM, Schau, M, Hamvas, A, Weese-Mayer, DE, Huang, Y, Lee, SM, Lee, CH, Shanbhag, NR, Paller, AS, Xu, S & Rogers, JA 2019, 'Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care', Science, vol. 363, no. 6430. https://doi.org/10.1126/science.aau0780

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title = "Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care",

abstract = "Existing vital sign monitoring systems in the neonatal intensive care unit (NICU) require multiple wires connected to rigid sensors with strongly adherent interfaces to the skin. We introduce a pair of ultrathin, soft, skin-like electronic devices whose coordinated, wireless operation reproduces the functionality of these traditional technologies but bypasses their intrinsic limitations. The enabling advances in engineering science include designs that support wireless, battery-free operation; real-time, in-sensor data analytics; time-synchronized, continuous data streaming; soft mechanics and gentle adhesive interfaces to the skin; and compatibility with visual inspection and with medical imaging techniques used in the NICU. Preliminary studies on neonates admitted to operating NICUs demonstrate performance comparable to the most advanced clinical-standard monitoring systems.",

author = "Chung, {Ha Uk} and Kim, {Bong Hoon} and Lee, {Jong Yoon} and Jungyup Lee and Zhaoqian Xie and Ibler, {Erin M.} and Lee, {Kun Hyuck} and Anthony Banks and Jeong, {Ji Yoon} and Jongwon Kim and Christopher Ogle and Dominic Grande and Yongjoon Yu and Hokyung Jang and Pourya Assem and Dennis Ryu and Kwak, {Jean Won} and Myeong Namkoong and Park, {Jun Bin} and Yechan Lee and Kim, {Do Hoon} and Arin Ryu and Jaeseok Jeong and Kevin You and Bowen Ji and Zhuangjian Liu and Qingze Huo and Xue Feng and Yujun Deng and Yeshou Xu and Jang, {Kyung In} and Jeonghyun Kim and Yihui Zhang and Roozbeh Ghaffari and Rand, {Casey M.} and Molly Schau and Aaron Hamvas and Weese-Mayer, {Debra E.} and Yonggang Huang and Lee, {Seung Min} and Lee, {Chi Hwan} and Shanbhag, {Naresh R.} and Paller, {Amy S.} and Shuai Xu and Rogers, {John A.}",

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doi = "10.1126/science.aau0780",

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AU - Chung, Ha Uk

AU - Kim, Bong Hoon

AU - Lee, Jong Yoon

AU - Lee, Jungyup

AU - Xie, Zhaoqian

AU - Ibler, Erin M.

AU - Lee, Kun Hyuck

AU - Banks, Anthony

AU - Jeong, Ji Yoon

AU - Kim, Jongwon

AU - Ogle, Christopher

AU - Grande, Dominic

AU - Yu, Yongjoon

AU - Jang, Hokyung

AU - Assem, Pourya

AU - Ryu, Dennis

AU - Kwak, Jean Won

AU - Namkoong, Myeong

AU - Park, Jun Bin

AU - Lee, Yechan

AU - Kim, Do Hoon

AU - Ryu, Arin

AU - Jeong, Jaeseok

AU - You, Kevin

AU - Ji, Bowen

AU - Liu, Zhuangjian

AU - Huo, Qingze

AU - Feng, Xue

AU - Deng, Yujun

AU - Xu, Yeshou

AU - Jang, Kyung In

AU - Kim, Jeonghyun

AU - Zhang, Yihui

AU - Ghaffari, Roozbeh

AU - Rand, Casey M.

AU - Schau, Molly

AU - Hamvas, Aaron

AU - Weese-Mayer, Debra E.

AU - Huang, Yonggang

AU - Lee, Seung Min

AU - Lee, Chi Hwan

AU - Shanbhag, Naresh R.

AU - Paller, Amy S.

AU - Xu, Shuai

AU - Rogers, John A.

PY - 2019

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AB - Existing vital sign monitoring systems in the neonatal intensive care unit (NICU) require multiple wires connected to rigid sensors with strongly adherent interfaces to the skin. We introduce a pair of ultrathin, soft, skin-like electronic devices whose coordinated, wireless operation reproduces the functionality of these traditional technologies but bypasses their intrinsic limitations. The enabling advances in engineering science include designs that support wireless, battery-free operation; real-time, in-sensor data analytics; time-synchronized, continuous data streaming; soft mechanics and gentle adhesive interfaces to the skin; and compatibility with visual inspection and with medical imaging techniques used in the NICU. Preliminary studies on neonates admitted to operating NICUs demonstrate performance comparable to the most advanced clinical-standard monitoring systems.

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Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care

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