Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes

Sunmi Seok; Deepthi Kanamaluru; Zhen Xiao; Daniel Ryerson; Sung E. Choi; Kelly Suino-Powell; H. Eric Xu; Timothy D. Veenstra; Jongsook Kim Kemper

doi:10.1074/jbc.M113.452037

Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes

Sunmi Seok, Deepthi Kanamaluru, Zhen Xiao, Daniel Ryerson, Sung E. Choi, Kelly Suino-Powell, H. Eric Xu, Timothy D. Veenstra, Jongsook Kim Kemper

Molecular and Integrative Physiology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Small heterodimer partner (SHP) is a key mediator of bile acid signaling. Results: Bile acid signal-induced phosphorylation at Thr-55 by protein kinase Cζ is important for SHP-mediated recruitment of chromatin modifiers and histone modifications. Conclusion: Thr-55 phosphorylation is critical for epigenomic regulation of liver metabolic genes. Significance: SHP Thr-55 phosphorylation may potentially provide a therapeutic target for bile acid-related diseases.

Original language	English (US)
Pages (from-to)	23252-23263
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M113.452037
State	Published - Aug 9 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Seok, S., Kanamaluru, D., Xiao, Z., Ryerson, D., Choi, S. E., Suino-Powell, K., Xu, H. E., Veenstra, T. D., & Kemper, J. K. (2013). Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes. Journal of Biological Chemistry, 288(32), 23252-23263. https://doi.org/10.1074/jbc.M113.452037

Seok, S, Kanamaluru, D, Xiao, Z, Ryerson, D, Choi, SE, Suino-Powell, K, Xu, HE, Veenstra, TD & Kemper, JK 2013, 'Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes', Journal of Biological Chemistry, vol. 288, no. 32, pp. 23252-23263. https://doi.org/10.1074/jbc.M113.452037

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abstract = "Background: Small heterodimer partner (SHP) is a key mediator of bile acid signaling. Results: Bile acid signal-induced phosphorylation at Thr-55 by protein kinase Cζ is important for SHP-mediated recruitment of chromatin modifiers and histone modifications. Conclusion: Thr-55 phosphorylation is critical for epigenomic regulation of liver metabolic genes. Significance: SHP Thr-55 phosphorylation may potentially provide a therapeutic target for bile acid-related diseases.",

author = "Sunmi Seok and Deepthi Kanamaluru and Zhen Xiao and Daniel Ryerson and Choi, {Sung E.} and Kelly Suino-Powell and Xu, {H. Eric} and Veenstra, {Timothy D.} and Kemper, {Jongsook Kim}",

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doi = "10.1074/jbc.M113.452037",

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AU - Seok, Sunmi

AU - Kanamaluru, Deepthi

AU - Xiao, Zhen

AU - Ryerson, Daniel

AU - Choi, Sung E.

AU - Suino-Powell, Kelly

AU - Xu, H. Eric

AU - Veenstra, Timothy D.

AU - Kemper, Jongsook Kim

PY - 2013/8/9

Y1 - 2013/8/9

N2 - Background: Small heterodimer partner (SHP) is a key mediator of bile acid signaling. Results: Bile acid signal-induced phosphorylation at Thr-55 by protein kinase Cζ is important for SHP-mediated recruitment of chromatin modifiers and histone modifications. Conclusion: Thr-55 phosphorylation is critical for epigenomic regulation of liver metabolic genes. Significance: SHP Thr-55 phosphorylation may potentially provide a therapeutic target for bile acid-related diseases.

AB - Background: Small heterodimer partner (SHP) is a key mediator of bile acid signaling. Results: Bile acid signal-induced phosphorylation at Thr-55 by protein kinase Cζ is important for SHP-mediated recruitment of chromatin modifiers and histone modifications. Conclusion: Thr-55 phosphorylation is critical for epigenomic regulation of liver metabolic genes. Significance: SHP Thr-55 phosphorylation may potentially provide a therapeutic target for bile acid-related diseases.

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Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes

Abstract

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