Research output per year
Research output per year
Won Jin Chung, Scott E. Denmark
Research output: Chapter in Book/Report/Conference proceeding › Chapter
One of the unique features of Lewis base catalysis is the capability of enhancing both nucleophilic and electrophilic characters within a molecule either through polarization or ionization of bonds upon coordination of a Lewis base onto the substrate. This chapter suggests to use either 'double activation catalysis' if both agents are acting on a single substrate or 'synergistic catalysis' if each agent activates a separate substrate. However, it is always possible that the Lewis base may simply serve as a ligand for the Lewis acid, which would constitute Lewis base activation of a Lewis acid. The chapter presents several leading accomplishments on the successful development of bifunctional or synergistic catalysis with mechanistic discussion as well as compilations of formally composed systems. The scope will be limited to the examples involving n Λ a*Lewis base activation, which is widely utilized for the addition of silylated nucleophiles to C=O or C=N double bonds.
Original language | English (US) |
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Title of host publication | Lewis Base Catalysis in Organic Synthesis |
Publisher | Wiley-VCH |
Pages | 1213-1258 |
Number of pages | 46 |
Volume | 3 |
ISBN (Electronic) | 9783527675142 |
ISBN (Print) | 9783527336180 |
DOIs | |
State | Published - Aug 17 2016 |
Research output: Book/Report/Conference proceeding › Book