TY - JOUR
T1 - Bidirectional regulation of distinct memory domains by α5-subunit-containing GABAA receptors in CA1 pyramidal neurons
AU - Engin, Elif
AU - Sigal, Maksim
AU - Benke, Dietmar
AU - Zeller, Anja
AU - Rudolph, Uwe
N1 - Funding Information:
This work was supported by award numbers R01GM086448 (U.R.), R01GM128183 (U.R.), and K01MH107787 (E.E.). In the last 2 years, U.R. has served as a consultant for Concert Pharmaceuticals. We thank Dr. Susumu Tonegawa (HHMI, Massachusetts Institute of Technology) for providing the T29-1 mice.
PY - 2020/10
Y1 - 2020/10
N2 - Reduction in the expression or function of α5-subunit-containing GABAA receptors (α5GABAARs) leads to improvement in several hippocampus-dependent memory domains. However, studies thus far mostly lack anatomical specificity in terms of neuronal circuits and populations. We demonstrate that mice with a selective knockdown of α5GABAARs in CA1 pyramidal neurons (α5CA1KO mice) show improved spatial and trace fear-conditioning memory. Unexpectedly, α5CA1KO mice were comparable to controls in contextual fear-conditioning but showed an impairment in context discrimination, suggesting fine-tuning of activity in CA1 pyramidal cell dendrites through α5-mediated inhibition might be necessary for distinguishing highly similar contexts.
AB - Reduction in the expression or function of α5-subunit-containing GABAA receptors (α5GABAARs) leads to improvement in several hippocampus-dependent memory domains. However, studies thus far mostly lack anatomical specificity in terms of neuronal circuits and populations. We demonstrate that mice with a selective knockdown of α5GABAARs in CA1 pyramidal neurons (α5CA1KO mice) show improved spatial and trace fear-conditioning memory. Unexpectedly, α5CA1KO mice were comparable to controls in contextual fear-conditioning but showed an impairment in context discrimination, suggesting fine-tuning of activity in CA1 pyramidal cell dendrites through α5-mediated inhibition might be necessary for distinguishing highly similar contexts.
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U2 - 10.1101/lm.052084.120
DO - 10.1101/lm.052084.120
M3 - Article
C2 - 32934095
SN - 1072-0502
VL - 27
SP - 423
EP - 428
JO - Learning & memory (Cold Spring Harbor, N.Y.)
JF - Learning & memory (Cold Spring Harbor, N.Y.)
IS - 10
ER -