Abstract
We describe a prospective strategy for reading the encyclopedic information encoded in the genome: using a nanopore in a membrane formed from a metal-oxide semiconductor (MOS)-capacitor to sense the charge in deoxyribonucleic acid (DNA). In principle, as DNA permeates the capacitor-membrane through the pore, the electrostatic charge distribution characteristic of the molecule should polarize the capacitor and induce a voltage on the electrodes that can be measured. Silicon nanofabrication and molecular dynamic simulations with atomic detail are technological linchpins in the development of this detector. The sub-nanometer precision available through silicon nanotechnology facilitates the fabrication of the detector, and molecular dynamics provides us with a means to design it and analyze the experimental outcomes.
Original language | English (US) |
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Pages (from-to) | 5-22 |
Number of pages | 18 |
Journal | Bell System Technical Journal |
Volume | 10 |
Issue number | 3 |
DOIs | |
State | Published - 2005 |
ASJC Scopus subject areas
- General Engineering