Abstract
The use of DNA as a material for nanoscale construction has blossomed in the past decade. This is largely attributable to the DNA origami technique, which has enabled construction of nanostructures ranging from simple two-dimensional sheets to complex three-dimensional objects with defined curves and edges. These structures are amenable to site-specific functionalization with nanometer precision, and have been shown to exhibit cellular biocompatibility and permeability. The DNA origami technique has already found widespread use in a variety of emerging biological applications such as biosensing, enzyme cascades, biomolecular analysis, biomimetics, and drug delivery. We highlight a few of these applications and comments on the prospects for this rapidly expanding field of research.
Original language | English (US) |
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Pages (from-to) | 1081-1089 |
Number of pages | 9 |
Journal | ChemBioChem |
DOIs | |
State | Published - Jun 16 2016 |
Externally published | Yes |
Keywords
- designer DNA
- DNA origami
- DNA structures
- G-Quadruplexes
- nanotechnology
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry