Beyond the Fold: Emerging Biological Applications of DNA Origami

Arun Richard Chandrasekaran, Nate Anderson, Megan Kizer, Ken Halvorsen, Xing Wang

Research output: Contribution to journalReview articlepeer-review

Abstract

The use of DNA as a material for nanoscale construction has blossomed in the past decade. This is largely attributable to the DNA origami technique, which has enabled construction of nanostructures ranging from simple two-dimensional sheets to complex three-dimensional objects with defined curves and edges. These structures are amenable to site-specific functionalization with nanometer precision, and have been shown to exhibit cellular biocompatibility and permeability. The DNA origami technique has already found widespread use in a variety of emerging biological applications such as biosensing, enzyme cascades, biomolecular analysis, biomimetics, and drug delivery. We highlight a few of these applications and comments on the prospects for this rapidly expanding field of research.

Original languageEnglish (US)
Pages (from-to)1081-1089
Number of pages9
JournalChemBioChem
DOIs
StatePublished - Jun 16 2016
Externally publishedYes

Keywords

  • designer DNA
  • DNA origami
  • DNA structures
  • G-Quadruplexes
  • nanotechnology

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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