BENDing with Polycomb in pluripotency and cancer

Abid Khan, Supriya Prasanth

Research output: Contribution to journalComment/debatepeer-review

Abstract

Three recent publications on BEND3 firmly establish its role as a novel sequence-specific transcription factor that is essential for PRC2 recruitment and maintenance of pluripotency. Here, we briefly review our current understanding of the BEND3-PRC2 axis in the regulation of pluripotency and also explore the possibility of a similar connection in cancer.

Original languageEnglish (US)
Article number2300046
JournalBioEssays
Volume45
Issue number8
DOIs
StatePublished - Aug 2023

Keywords

  • BEND3
  • EZH2
  • PRC2
  • pluripotency
  • stem cells

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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