Abstract
Three recent publications on BEND3 firmly establish its role as a novel sequence-specific transcription factor that is essential for PRC2 recruitment and maintenance of pluripotency. Here, we briefly review our current understanding of the BEND3-PRC2 axis in the regulation of pluripotency and also explore the possibility of a similar connection in cancer.
Original language | English (US) |
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Article number | 2300046 |
Journal | BioEssays |
Volume | 45 |
Issue number | 8 |
DOIs |
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State | Published - Aug 2023 |
Keywords
- BEND3
- EZH2
- PRC2
- pluripotency
- stem cells
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology