Behavioral functions of GABAA receptor subtypes - The zurich experience

Florence Crestani, Uwe Rudolph

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

GABAA receptors are the major inhibitory neurotransmitter receptors in the brain. They are heteropentamers that are typically classified according to their α subunits. By rendering each of the benzodiazepine-sensitive α subunits (α1, α2, α3, and α5) insensitive to modulation by classical benzodiazepines by His to Arg point mutations in knock-in mice, we were able to identify behavioral functions mediated by different GABAA receptor subtypes, which led to the development of novel therapeutic strategies. In this chapter, we provide a largely chronological overview on behavioral studies on GABAA receptor mutant mice at the Institute of Pharmacology and Toxicology at the University of Zurich.

Original languageEnglish (US)
Title of host publicationAdvances in Pharmacology
PublisherAcademic Press Inc.
Pages37-51
Number of pages15
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Publication series

NameAdvances in Pharmacology
Volume72
ISSN (Print)1054-3589
ISSN (Electronic)1557-8925

Keywords

  • Benzodiazepines
  • GABA receptor
  • Genetically modified mice

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Crestani, F., & Rudolph, U. (2015). Behavioral functions of GABAA receptor subtypes - The zurich experience. In Advances in Pharmacology (pp. 37-51). (Advances in Pharmacology; Vol. 72). Academic Press Inc.. https://doi.org/10.1016/bs.apha.2014.10.001