Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF-κB by TNF

Hugo Albrecht, Jürg Tschopp, C. Victor Jongeneel

Research output: Contribution to journalArticlepeer-review

Abstract

The recent demonstration of the anti-oxidant properties of the Bcl-2 gene product suggested that expression of Bcl-2 may interfere with the nuclear migration of the NF-κB transcription factor, which is thought to depend on the presence of reactive oxygen intermediates. In mouse L cells, overexpression of Bcl-2 interfered with the activation of NF-κB by H2O2. However, Bcl-2 had no effect on the activation of NF-κB by TNF, even though it protected cells from TNF-induced apoptosis. The effects of exogenous pyrrolidine dithiocarbamate were very similar to those of Bcl-2 overexpression. We conclude that the protective effects of anti-oxidants against induced apoptotic cell death are unrelated to their ability to interfere with NF-κB activation.

Original languageEnglish (US)
Pages (from-to)45-48
Number of pages4
JournalFEBS Letters
Volume351
Issue number1
DOIs
StatePublished - Aug 29 1994

Keywords

  • Apoptosis
  • Bcl-2
  • NF-κB
  • Reactive oxygen species
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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