Balancing biofunctional and biomechanical properties using porous titanium reinforced by carbon nanotubes

Juan Jose Pavón, Diana López, Fanor Mondragón, Jaime Gallego, Sandra L. Arias, Kara Luitjohan, Brandon Holybee, Yadir Torres, José A. Rodríguez, Mónica Echeverry-Rendón, Ana Civantos, Jean Paul Allain

Research output: Contribution to journalArticle

Abstract

Despite the well-known advantages of the titanium-based implant systems, they still lack an optimal balance between biofunctionality and mechanical strength, especially regarding the modulation of cellular response and a desired implant osseointegration. In this work, we fabricated a nanocomposite based on porous commercially pure grade 4 titanium (c.p. Ti) reinforced with carbon nanotubes (CNT) at 5% and 10% w/w, with the aim of obtaining a nanocomposite with lower stiffness compared to traditional titanium-based implants and with the mechanical strength and bioactivity owed by the CNT. Results obtained by scanning electron microscopy, X-ray photoelectron spectroscopy, and atomic force microscopy characterization showed that the CNT dispersed and incorporated into the porous c.p. Ti matrix. Interestingly, CNT were associated with a higher twining within neighbor Ti grains, which was indeed consistent with an increased in nano-hardness. Biological evaluation by MTT and Comet assay revealed that the nanocomposites did not induce genotoxicity and cytotoxicity on two different cells lines despite the presence of nickel at the surface. Accordingly, a purification step would be required before these CNT can be used for biomedical applications. Our results indicate that incorporation of CNT into porous c.p. Ti is a promising avenue to achieve an adequate balance between biofunctionality and mechanical strength in Ti-based scaffolds for tissue replacement.

Original languageEnglish (US)
Pages (from-to)719-731
Number of pages13
JournalJournal of Biomedical Materials Research - Part A
Volume107
Issue number4
DOIs
StatePublished - Apr 2019

Fingerprint

Carbon Nanotubes
Titanium
Carbon nanotubes
Strength of materials
Nanocomposites
Nanohardness
Tissue Scaffolds
Cytotoxicity
Bioactivity
Nickel
Scaffolds
Purification
Assays
Atomic force microscopy
X ray photoelectron spectroscopy
Cells
Stiffness
Modulation
Tissue
Scanning electron microscopy

Keywords

  • advanced biointerfaces
  • bone replacement
  • carbon nanotubes
  • stress-shielding
  • titanium implants

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Cite this

Pavón, J. J., López, D., Mondragón, F., Gallego, J., Arias, S. L., Luitjohan, K., ... Allain, J. P. (2019). Balancing biofunctional and biomechanical properties using porous titanium reinforced by carbon nanotubes. Journal of Biomedical Materials Research - Part A, 107(4), 719-731. https://doi.org/10.1002/jbm.a.36586

Balancing biofunctional and biomechanical properties using porous titanium reinforced by carbon nanotubes. / Pavón, Juan Jose; López, Diana; Mondragón, Fanor; Gallego, Jaime; Arias, Sandra L.; Luitjohan, Kara; Holybee, Brandon; Torres, Yadir; Rodríguez, José A.; Echeverry-Rendón, Mónica; Civantos, Ana; Allain, Jean Paul.

In: Journal of Biomedical Materials Research - Part A, Vol. 107, No. 4, 04.2019, p. 719-731.

Research output: Contribution to journalArticle

Pavón, JJ, López, D, Mondragón, F, Gallego, J, Arias, SL, Luitjohan, K, Holybee, B, Torres, Y, Rodríguez, JA, Echeverry-Rendón, M, Civantos, A & Allain, JP 2019, 'Balancing biofunctional and biomechanical properties using porous titanium reinforced by carbon nanotubes', Journal of Biomedical Materials Research - Part A, vol. 107, no. 4, pp. 719-731. https://doi.org/10.1002/jbm.a.36586
Pavón, Juan Jose ; López, Diana ; Mondragón, Fanor ; Gallego, Jaime ; Arias, Sandra L. ; Luitjohan, Kara ; Holybee, Brandon ; Torres, Yadir ; Rodríguez, José A. ; Echeverry-Rendón, Mónica ; Civantos, Ana ; Allain, Jean Paul. / Balancing biofunctional and biomechanical properties using porous titanium reinforced by carbon nanotubes. In: Journal of Biomedical Materials Research - Part A. 2019 ; Vol. 107, No. 4. pp. 719-731.
@article{6d2514a1280e4a638c7fda8b3e4f9038,
title = "Balancing biofunctional and biomechanical properties using porous titanium reinforced by carbon nanotubes",
abstract = "Despite the well-known advantages of the titanium-based implant systems, they still lack an optimal balance between biofunctionality and mechanical strength, especially regarding the modulation of cellular response and a desired implant osseointegration. In this work, we fabricated a nanocomposite based on porous commercially pure grade 4 titanium (c.p. Ti) reinforced with carbon nanotubes (CNT) at 5{\%} and 10{\%} w/w, with the aim of obtaining a nanocomposite with lower stiffness compared to traditional titanium-based implants and with the mechanical strength and bioactivity owed by the CNT. Results obtained by scanning electron microscopy, X-ray photoelectron spectroscopy, and atomic force microscopy characterization showed that the CNT dispersed and incorporated into the porous c.p. Ti matrix. Interestingly, CNT were associated with a higher twining within neighbor Ti grains, which was indeed consistent with an increased in nano-hardness. Biological evaluation by MTT and Comet assay revealed that the nanocomposites did not induce genotoxicity and cytotoxicity on two different cells lines despite the presence of nickel at the surface. Accordingly, a purification step would be required before these CNT can be used for biomedical applications. Our results indicate that incorporation of CNT into porous c.p. Ti is a promising avenue to achieve an adequate balance between biofunctionality and mechanical strength in Ti-based scaffolds for tissue replacement.",
keywords = "advanced biointerfaces, bone replacement, carbon nanotubes, stress-shielding, titanium implants",
author = "Pav{\'o}n, {Juan Jose} and Diana L{\'o}pez and Fanor Mondrag{\'o}n and Jaime Gallego and Arias, {Sandra L.} and Kara Luitjohan and Brandon Holybee and Yadir Torres and Rodr{\'i}guez, {Jos{\'e} A.} and M{\'o}nica Echeverry-Rend{\'o}n and Ana Civantos and Allain, {Jean Paul}",
year = "2019",
month = "4",
doi = "10.1002/jbm.a.36586",
language = "English (US)",
volume = "107",
pages = "719--731",
journal = "Journal of Biomedical Materials Research - Part A",
issn = "1549-3296",
publisher = "Heterocorporation",
number = "4",

}

TY - JOUR

T1 - Balancing biofunctional and biomechanical properties using porous titanium reinforced by carbon nanotubes

AU - Pavón, Juan Jose

AU - López, Diana

AU - Mondragón, Fanor

AU - Gallego, Jaime

AU - Arias, Sandra L.

AU - Luitjohan, Kara

AU - Holybee, Brandon

AU - Torres, Yadir

AU - Rodríguez, José A.

AU - Echeverry-Rendón, Mónica

AU - Civantos, Ana

AU - Allain, Jean Paul

PY - 2019/4

Y1 - 2019/4

N2 - Despite the well-known advantages of the titanium-based implant systems, they still lack an optimal balance between biofunctionality and mechanical strength, especially regarding the modulation of cellular response and a desired implant osseointegration. In this work, we fabricated a nanocomposite based on porous commercially pure grade 4 titanium (c.p. Ti) reinforced with carbon nanotubes (CNT) at 5% and 10% w/w, with the aim of obtaining a nanocomposite with lower stiffness compared to traditional titanium-based implants and with the mechanical strength and bioactivity owed by the CNT. Results obtained by scanning electron microscopy, X-ray photoelectron spectroscopy, and atomic force microscopy characterization showed that the CNT dispersed and incorporated into the porous c.p. Ti matrix. Interestingly, CNT were associated with a higher twining within neighbor Ti grains, which was indeed consistent with an increased in nano-hardness. Biological evaluation by MTT and Comet assay revealed that the nanocomposites did not induce genotoxicity and cytotoxicity on two different cells lines despite the presence of nickel at the surface. Accordingly, a purification step would be required before these CNT can be used for biomedical applications. Our results indicate that incorporation of CNT into porous c.p. Ti is a promising avenue to achieve an adequate balance between biofunctionality and mechanical strength in Ti-based scaffolds for tissue replacement.

AB - Despite the well-known advantages of the titanium-based implant systems, they still lack an optimal balance between biofunctionality and mechanical strength, especially regarding the modulation of cellular response and a desired implant osseointegration. In this work, we fabricated a nanocomposite based on porous commercially pure grade 4 titanium (c.p. Ti) reinforced with carbon nanotubes (CNT) at 5% and 10% w/w, with the aim of obtaining a nanocomposite with lower stiffness compared to traditional titanium-based implants and with the mechanical strength and bioactivity owed by the CNT. Results obtained by scanning electron microscopy, X-ray photoelectron spectroscopy, and atomic force microscopy characterization showed that the CNT dispersed and incorporated into the porous c.p. Ti matrix. Interestingly, CNT were associated with a higher twining within neighbor Ti grains, which was indeed consistent with an increased in nano-hardness. Biological evaluation by MTT and Comet assay revealed that the nanocomposites did not induce genotoxicity and cytotoxicity on two different cells lines despite the presence of nickel at the surface. Accordingly, a purification step would be required before these CNT can be used for biomedical applications. Our results indicate that incorporation of CNT into porous c.p. Ti is a promising avenue to achieve an adequate balance between biofunctionality and mechanical strength in Ti-based scaffolds for tissue replacement.

KW - advanced biointerfaces

KW - bone replacement

KW - carbon nanotubes

KW - stress-shielding

KW - titanium implants

UR - http://www.scopus.com/inward/record.url?scp=85058396201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058396201&partnerID=8YFLogxK

U2 - 10.1002/jbm.a.36586

DO - 10.1002/jbm.a.36586

M3 - Article

C2 - 30474272

AN - SCOPUS:85058396201

VL - 107

SP - 719

EP - 731

JO - Journal of Biomedical Materials Research - Part A

JF - Journal of Biomedical Materials Research - Part A

SN - 1549-3296

IS - 4

ER -