TY - GEN
T1 - BACTERICIDAL EFFECTS OF MICROPILLARS
T2 - ASME 2022 International Mechanical Engineering Congress and Exposition, IMECE 2022
AU - Singh, Akash
AU - Li, Yumeng
N1 - The authors acknowledge the support provided by University of Illinois at Urbana Champaign and NSF support under Grant No. 2015292. All MD simulations were done by using LAMMPS, an open source code distributed by Sandia National Laboratories.
PY - 2022
Y1 - 2022
N2 - Previous studies have shown that cicada wings has the ability to kill the bacteria on contact. Study of natural bactericidal surface in cicada wings has opened new dimensions of scientific research in bio-inspired chemical-free bactericidal surfaces. To develop and design such biomimetic bactericidal surface, it is necessary to understand the mechanical bactericidal effects of nanopillars in the presence of bacteria, which is extremely challenging due to the small relevant length and time scales. In this study, we have conducted molecular dynamics (MD) simulations to investigate the biomimetic surface with various nanopillars configurations. MD simulations is an exceptional method to simulate materials with small time and length scales with good accuracy and low computational costs. We have simulated the bacteria's model using coarse-grained modelling and conducting MD simulations. Effects of nanopillar spacing, diameter and height on the lysis process is studied in this article. It is expected that this study will provide us insights on designing nanopillars in terms of height, spacing and diameter for optimal bactericidal effects that can help in the development of chemical-free antibacterial surface.
AB - Previous studies have shown that cicada wings has the ability to kill the bacteria on contact. Study of natural bactericidal surface in cicada wings has opened new dimensions of scientific research in bio-inspired chemical-free bactericidal surfaces. To develop and design such biomimetic bactericidal surface, it is necessary to understand the mechanical bactericidal effects of nanopillars in the presence of bacteria, which is extremely challenging due to the small relevant length and time scales. In this study, we have conducted molecular dynamics (MD) simulations to investigate the biomimetic surface with various nanopillars configurations. MD simulations is an exceptional method to simulate materials with small time and length scales with good accuracy and low computational costs. We have simulated the bacteria's model using coarse-grained modelling and conducting MD simulations. Effects of nanopillar spacing, diameter and height on the lysis process is studied in this article. It is expected that this study will provide us insights on designing nanopillars in terms of height, spacing and diameter for optimal bactericidal effects that can help in the development of chemical-free antibacterial surface.
KW - Bacteria-nanopillar interaction
KW - Biomimetic bactericidal surface
KW - CGMD
KW - MD
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U2 - 10.1115/IMECE2022-95325
DO - 10.1115/IMECE2022-95325
M3 - Conference contribution
AN - SCOPUS:85148452588
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
BT - Advanced Materials
PB - American Society of Mechanical Engineers (ASME)
Y2 - 30 October 2022 through 3 November 2022
ER -