Bacterial social interactions drive the emergence of differential spatial colony structures

Andrew E. Blanchard, Ting Lu

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Social interactions have been increasingly recognized as one of the major factors that contribute to the dynamics and function of bacterial communities. To understand their functional roles and enable the design of robust synthetic consortia, one fundamental step is to determine the relationship between the social interactions of individuals and the spatiotemporal structures of communities. Results: We present a systematic computational survey on this relationship for two-species communities by developing and utilizing a hybrid computational framework that combines discrete element techniques with reaction-diffusion equations. We found that deleterious interactions cause an increased variance in relative abundance, a drastic decrease in surviving lineages, and a rough expanding front. In contrast, beneficial interactions contribute to a reduced variance in relative abundance, an enhancement in lineage number, and a smooth expanding front. We also found that mutualism promotes spatial homogeneity and population robustness while competition increases spatial segregation and population fluctuations. To examine the generality of these findings, a large set of initial conditions with varying density and species abundance was tested and analyzed. In addition, a simplified mathematical model was developed to provide an analytical interpretation of the findings. Conclusions: This work advances our fundamental understanding of bacterial social interactions and population structures and, simultaneously, benefits synthetic biology for facilitated engineering of artificial microbial consortia.

Original languageEnglish (US)
Article number59
JournalBMC Systems Biology
Volume9
Issue number1
DOIs
StatePublished - Sep 16 2015

Keywords

  • Bacterial colonies
  • Community structures
  • Social interactions
  • Spatiotemporal patterns

ASJC Scopus subject areas

  • Structural Biology
  • Modeling and Simulation
  • Molecular Biology
  • Computer Science Applications
  • Applied Mathematics

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