Bacterial fatty acid biosynthesis: Targets for antibacterial drug discovery

J. W. Campbell, Jr Cronan

Research output: Contribution to journalReview article

Abstract

The increase in drug-resistant pathogenic bacteria has created an urgent demand for new antibiotics. Among the more attractive targets for the development of new antibacterial compounds are the enzymes of fatty acid biosynthesis. Although a number of potent inhibitors of microbial fatty acid biosynthesis have been discovered, few of these are clinically useful drugs. Several of these fatty acid biosynthesis inhibitors have potential as lead compounds in the development of new antibacterials. This review encompasses the known inhibitors and prospective targets for new antibacterials.

Original languageEnglish (US)
Pages (from-to)305-332
Number of pages28
JournalAnnual review of microbiology
Volume55
DOIs
StatePublished - Oct 29 2001

Keywords

  • Cerulenin
  • Diazoborine
  • Isoniazid
  • Thiolactomycin
  • Triclosan

ASJC Scopus subject areas

  • Microbiology

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