TY - JOUR
T1 - Bacteria in Fluid Flow
AU - Padron, Gilberto C.
AU - Shuppara, Alexander M.
AU - Palalay, Jessica Jae S.
AU - Sharma, Anuradha
AU - Sanfilippo, Joseph E.
N1 - Publisher Copyright:
Copyright © 2023 American Society for Microbiology. All Rights Reserved.
PY - 2023/4
Y1 - 2023/4
N2 - Bacteria thrive in environments rich in fluid flow, such as the gastrointestinal tract, bloodstream, aquatic systems, and the urinary tract. Despite the importance of flow, how flow affects bacterial life is underappreciated. In recent years, the combination of approaches from biology, physics, and engineering has led to a deeper understanding of how bacteria interact with flow. Here, we highlight the wide range of bacterial responses to flow, including changes in surface adhesion, motility, surface colonization, quorum sensing, virulence factor production, and gene expression. To emphasize the diversity of flow responses, we focus our review on how flow affects four ecologically distinct bacterial species: Escherichia coli, Staphylococcus aureus, Caulobacter crescentus, and Pseudomonas aeruginosa. Additionally, we present experimental approaches to precisely study bacteria in flow, discuss how only some flow responses are triggered by shear force, and provide perspective on flow-sensitive bacterial signaling.
AB - Bacteria thrive in environments rich in fluid flow, such as the gastrointestinal tract, bloodstream, aquatic systems, and the urinary tract. Despite the importance of flow, how flow affects bacterial life is underappreciated. In recent years, the combination of approaches from biology, physics, and engineering has led to a deeper understanding of how bacteria interact with flow. Here, we highlight the wide range of bacterial responses to flow, including changes in surface adhesion, motility, surface colonization, quorum sensing, virulence factor production, and gene expression. To emphasize the diversity of flow responses, we focus our review on how flow affects four ecologically distinct bacterial species: Escherichia coli, Staphylococcus aureus, Caulobacter crescentus, and Pseudomonas aeruginosa. Additionally, we present experimental approaches to precisely study bacteria in flow, discuss how only some flow responses are triggered by shear force, and provide perspective on flow-sensitive bacterial signaling.
KW - adhesion
KW - bacteria
KW - colonization
KW - fluid flow
KW - gene expression
KW - mechanobiology
KW - mechanosensing
KW - motility
KW - quorum sensing
KW - virulence
UR - http://www.scopus.com/inward/record.url?scp=85153900943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85153900943&partnerID=8YFLogxK
U2 - 10.1128/jb.00400-22
DO - 10.1128/jb.00400-22
M3 - Review article
C2 - 36951552
AN - SCOPUS:85153900943
SN - 0021-9193
VL - 205
JO - Journal of bacteriology
JF - Journal of bacteriology
IS - 4
ER -