The Bacillus subtilis flhA gene lies in the major che/fla operon, a transcription unit that spans 26 kilobases (kb) of DNA. flhA encodes a 677‐amino‐acid polypeptide that is a strong candidate for an integral membrane protein. The sequence of FlhA displays substantial homology to a newly identified family of putative signal‐transducing receptors that have been implicated in diverse cellular processes. FlhA is the first member of this family to be described from a Gram‐positive bacterium. We demonstrate that flhA is a flagellar gene and that FlhA is required in trans for the formation of products from some, but not all, B. subtilis motility‐related operons that are regulated by the αD form of RNA polymerase. We suggest that FlhA is a component of a signalling system that is involved with the formation of some flagellar gene products during the biosynthesis of the flagellum.
|Original language||English (US)|
|Number of pages||9|
|State||Published - Mar 1993|
ASJC Scopus subject areas
- Molecular Biology