Bacillus subtilis FlhA: a flagellar protein related to a new family of signal‐transducing receptors

Phillip B. Carpenter, George W Ordal

Research output: Contribution to journalArticle

Abstract

The Bacillus subtilis flhA gene lies in the major che/fla operon, a transcription unit that spans 26 kilobases (kb) of DNA. flhA encodes a 677‐amino‐acid polypeptide that is a strong candidate for an integral membrane protein. The sequence of FlhA displays substantial homology to a newly identified family of putative signal‐transducing receptors that have been implicated in diverse cellular processes. FlhA is the first member of this family to be described from a Gram‐positive bacterium. We demonstrate that flhA is a flagellar gene and that FlhA is required in trans for the formation of products from some, but not all, B. subtilis motility‐related operons that are regulated by the αD form of RNA polymerase. We suggest that FlhA is a component of a signalling system that is involved with the formation of some flagellar gene products during the biosynthesis of the flagellum.

Original languageEnglish (US)
Pages (from-to)735-743
Number of pages9
JournalMolecular Microbiology
Volume7
Issue number5
DOIs
StatePublished - Mar 1993

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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