Axon-First Neuritogenesis on Vertical Nanowires

Kyungtae Kang; Yi Seul Park; Matthew Park; Min Jee Jang; Seong Min Kim; Juno Lee; Ji Yu Choi; Da Hee Jung; Young Tae Chang; Myung Han Yoon; Jin Seok Lee; Yoonkey Nam; Insung S. Choi

doi:10.1021/acs.nanolett.5b04458

Axon-First Neuritogenesis on Vertical Nanowires

Kyungtae Kang, Yi Seul Park, Matthew Park, Min Jee Jang, Seong Min Kim, Juno Lee, Ji Yu Choi, Da Hee Jung, Young Tae Chang, Myung Han Yoon, Jin Seok Lee, Yoonkey Nam, Insung S. Choi

Research output: Contribution to journal › Article › peer-review

Abstract

In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarization. Additionally, the development of lamellipodia, which generally occurs on 2D culture coverslips, was absent on vg-SiNWs. The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo. (Figure Presented).

Original language	English (US)
Pages (from-to)	675-680
Number of pages	6
Journal	Nano letters
Volume	16
Issue number	1
DOIs	https://doi.org/10.1021/acs.nanolett.5b04458
State	Published - Jan 13 2016
Externally published	Yes

Keywords

chemical vapor deposition
F-actin dynamics
live-cell imaging
neurite development
primary hippocampal neuron
Silicon nanowires

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

Online availability

10.1021/acs.nanolett.5b04458

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title = "Axon-First Neuritogenesis on Vertical Nanowires",

abstract = "In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarization. Additionally, the development of lamellipodia, which generally occurs on 2D culture coverslips, was absent on vg-SiNWs. The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo. (Figure Presented).",

keywords = "chemical vapor deposition, F-actin dynamics, live-cell imaging, neurite development, primary hippocampal neuron, Silicon nanowires",

author = "Kyungtae Kang and Park, {Yi Seul} and Matthew Park and Jang, {Min Jee} and Kim, {Seong Min} and Juno Lee and Choi, {Ji Yu} and Jung, {Da Hee} and Chang, {Young Tae} and Yoon, {Myung Han} and Lee, {Jin Seok} and Yoonkey Nam and Choi, {Insung S.}",

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doi = "10.1021/acs.nanolett.5b04458",

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T1 - Axon-First Neuritogenesis on Vertical Nanowires

AU - Kang, Kyungtae

AU - Park, Yi Seul

AU - Park, Matthew

AU - Jang, Min Jee

AU - Kim, Seong Min

AU - Lee, Juno

AU - Choi, Ji Yu

AU - Jung, Da Hee

AU - Chang, Young Tae

AU - Yoon, Myung Han

AU - Lee, Jin Seok

AU - Nam, Yoonkey

AU - Choi, Insung S.

PY - 2016/1/13

Y1 - 2016/1/13

N2 - In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarization. Additionally, the development of lamellipodia, which generally occurs on 2D culture coverslips, was absent on vg-SiNWs. The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo. (Figure Presented).

AB - In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarization. Additionally, the development of lamellipodia, which generally occurs on 2D culture coverslips, was absent on vg-SiNWs. The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo. (Figure Presented).

KW - chemical vapor deposition

KW - F-actin dynamics

KW - live-cell imaging

KW - neurite development

KW - primary hippocampal neuron

KW - Silicon nanowires

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Axon-First Neuritogenesis on Vertical Nanowires

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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