Axon-First Neuritogenesis on Vertical Nanowires

Kyungtae Kang, Yi Seul Park, Matthew Park, Min Jee Jang, Seong Min Kim, Juno Lee, Ji Yu Choi, Da Hee Jung, Young Tae Chang, Myung Han Yoon, Jin Seok Lee, Yoonkey Nam, Insung S. Choi

Research output: Contribution to journalArticlepeer-review


In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarization. Additionally, the development of lamellipodia, which generally occurs on 2D culture coverslips, was absent on vg-SiNWs. The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)675-680
Number of pages6
JournalNano letters
Issue number1
StatePublished - Jan 13 2016
Externally publishedYes


  • chemical vapor deposition
  • F-actin dynamics
  • live-cell imaging
  • neurite development
  • primary hippocampal neuron
  • Silicon nanowires

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering


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