Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice

Keyphrases

• Autophagy 100%
• Male Mice 100%
• ATG5 100%
• Core Protein 100%
• Spermatid Development 100%
• Autophagy Pathway 50%
• Mutant Mice 37%
• SQSTM1 37%
• Quantitative PCR 25%
• Lumen 25%
• Spermiogenesis 25%
• Electron Microscopy 12%
• Autophagosome 12%
• Testicle 12%
• Germ Cells 12%
• Morphological Changes 12%
• Developmental Processes 12%
• Histological Examination 12%
• Resorption 12%
• Spermatozoa 12%
• Conditional Knockout 12%
• Multiple Signals 12%
• Protein Degradation 12%
• Acrosome 12%
• Macroautophagy 12%
• ATG7 12%
• Epididymal Sperm 12%
• Epididymis 12%
• Mitochondrial Damage 12%
• Male Germ Cells 12%
• Flox 12%
• Spermatogenesis 12%
• Cauda 12%
• Sperm Count 12%
• Male Infertility 12%
• Sperm Motility 12%
• ATG12 12%
• Seminiferous Epithelium 12%
• Residual Bodies 12%
• Anchoring Proteins 12%
• PIWI-interacting RNA (piRNA) 12%
• Autophagy-related Proteins 12%
• Sperm Head 12%
• Cauda Epididymal Sperm 12%
• Male Germ Cell Development 12%
• Acrosome Formation 12%
• Immunofluorescence Staining 12%
• DEAD-box Protein 12%
• Midpiece 12%
• Spermiation 12%
• AKAP4 12%
• Floxed 12%
• DDX4 12%
• MAP1LC3B 12%
• Microtubule-associated Protein 1 Light Chain 3 12%
• Accessory Structure 12%
• Cytoplasmic Bodies 12%
• Tubulobulbar Complexes 12%
• ATG10 12%
• PIWIL2 12%
• RNA-mediated Gene Silencing 12%
• PBS Phosphate Buffered Saline 12%
• LC3A 12%
• Autophagy Receptor 12%

Medicine and Dentistry

• Spermatid 100%
• Autophagy 100%
• Core Protein 100%
• Individualization 100%
• Autophagy Related Protein 5 100%
• Spermiogenesis 30%
• Germ Cell 30%
• Acrosome 20%
• Receptor 10%
• Morphology 10%
• Immunofluorescence 10%
• Mitochondrion 10%
• Tail 10%
• Large Cell 10%
• Protein Degradation 10%
• Electron Microscopy 10%
• Cyclic AMP Dependent Protein Kinase 10%
• Norfloxacin 10%
• Testes 10%
• Male Fertility 10%
• Cell Maturation 10%
• Reverse Transcription Polymerase Chain Reaction 10%
• Autophagosome 10%
• Light Chain 10%
• Phosphate Buffered Saline 10%
• Sequestosome 1 10%
• Macroautophagy 10%
• Microtubule Associated Protein 1 10%
• DEAD Box Protein 10%
• Reverse Transcription Polymerase Chain Reaction 10%
• Gene Inactivation 10%

Biochemistry, Genetics and Molecular Biology

• Autophagy 100%
• Spermatid 100%
• Individualization 100%
• ATG5 100%
• Germ Cell 30%
• Mouse Mutant 30%
• Spermatogenesis 30%
• Acrosome 20%
• RNA 10%
• Synapsin I 10%
• Helicase 10%
• Morphology 10%
• Protein Catabolism 10%
• Protein Kinase A 10%
• Electron Microscopy 10%
• Mitochondrion 10%
• Wild Type 10%
• Immunofluorescence 10%
• Cell Maturation 10%
• Light Chain 10%
• Reverse Transcription Polymerase Chain Reaction 10%
• Macroautophagy 10%
• Male Fertility 10%
• Gene Inactivation 10%
• Autophagosome 10%
• Piwi 10%
• Microtubule-Associated Protein 10%
• Phosphate Buffered Saline 10%
• DEAD Box 10%
• ATG7 10%
• Sequestosome 1 10%
• Reverse Transcription Polymerase Chain Reaction 10%