Autoinducer synthase modulating compounds and uses thereof

John E Cronan, Jr. (Inventor), E. Peter Greenberg (Inventor), Steven Turner (Inventor)

Research output: Patent


Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.
Original languageEnglish (US)
U.S. patent number6723321
Filing date1/6/99
StatePublished - Apr 20 2004


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