Auto-regulation of thyroid hormone receptors in the goldfish ovary and testis

Erik R. Nelson; Euan R.O. Allan; Flora Y. Pang; Hamid R. Habibi

doi:10.1016/j.ygcen.2010.12.017

Auto-regulation of thyroid hormone receptors in the goldfish ovary and testis

Erik R. Nelson, Euan R.O. Allan, Flora Y. Pang, Hamid R. Habibi

Research output: Contribution to journal › Article › peer-review

Abstract

Thyroid hormones, acting via their cognate thyroid receptors (TRs) act as mediators and modulators of several physiological processes and homeostasis. A clear role for the TRs in reproduction has not yet been established although several lines of recent evidence suggest that they are involved in the regulation of reproduction. To further study the role of TRs in control of reproduction, we investigated homologous regulation of TR subtypes in the gonads of goldfish, in vivo and in vitro. It was found that tri-iodothyronine (T₃) down-regulates the traditional TRs (TRα-1 and TRβ) and up-regulates a dominant-negative form, TRα-t. This indicates a 'feedback' mechanism whereby an acute treatment with T₃ down regulates further T₃ mediated response. The results provide novel information on auto-regulation of TRs in the goldfish ovary and testis, and support the hypothesis that thyroid hormones are involved in the control of reproduction.

Original language	English (US)
Pages (from-to)	50-55
Number of pages	6
Journal	General and Comparative Endocrinology
Volume	172
Issue number	1
DOIs	https://doi.org/10.1016/j.ygcen.2010.12.017
State	Published - May 15 2011
Externally published	Yes

Keywords

Goldfish
Gonads
Regulation
Reproduction
Thyroid hormone
Thyroid receptor

ASJC Scopus subject areas

Animal Science and Zoology
Endocrinology

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10.1016/j.ygcen.2010.12.017

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title = "Auto-regulation of thyroid hormone receptors in the goldfish ovary and testis",

abstract = "Thyroid hormones, acting via their cognate thyroid receptors (TRs) act as mediators and modulators of several physiological processes and homeostasis. A clear role for the TRs in reproduction has not yet been established although several lines of recent evidence suggest that they are involved in the regulation of reproduction. To further study the role of TRs in control of reproduction, we investigated homologous regulation of TR subtypes in the gonads of goldfish, in vivo and in vitro. It was found that tri-iodothyronine (T3) down-regulates the traditional TRs (TRα-1 and TRβ) and up-regulates a dominant-negative form, TRα-t. This indicates a 'feedback' mechanism whereby an acute treatment with T3 down regulates further T3 mediated response. The results provide novel information on auto-regulation of TRs in the goldfish ovary and testis, and support the hypothesis that thyroid hormones are involved in the control of reproduction.",

keywords = "Goldfish, Gonads, Regulation, Reproduction, Thyroid hormone, Thyroid receptor",

author = "Nelson, {Erik R.} and Allan, {Euan R.O.} and Pang, {Flora Y.} and Habibi, {Hamid R.}",

note = "Funding Information: This work was funded by NSERC grants to H.R.H. We also acknowledge a Government of Alberta Queen Elizabeth II graduate scholarship to E.R.N and a University of Calgary PURE scholarship to E.R.O.A.",

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AU - Nelson, Erik R.

AU - Allan, Euan R.O.

AU - Pang, Flora Y.

AU - Habibi, Hamid R.

N1 - Funding Information: This work was funded by NSERC grants to H.R.H. We also acknowledge a Government of Alberta Queen Elizabeth II graduate scholarship to E.R.N and a University of Calgary PURE scholarship to E.R.O.A.

PY - 2011/5/15

Y1 - 2011/5/15

N2 - Thyroid hormones, acting via their cognate thyroid receptors (TRs) act as mediators and modulators of several physiological processes and homeostasis. A clear role for the TRs in reproduction has not yet been established although several lines of recent evidence suggest that they are involved in the regulation of reproduction. To further study the role of TRs in control of reproduction, we investigated homologous regulation of TR subtypes in the gonads of goldfish, in vivo and in vitro. It was found that tri-iodothyronine (T3) down-regulates the traditional TRs (TRα-1 and TRβ) and up-regulates a dominant-negative form, TRα-t. This indicates a 'feedback' mechanism whereby an acute treatment with T3 down regulates further T3 mediated response. The results provide novel information on auto-regulation of TRs in the goldfish ovary and testis, and support the hypothesis that thyroid hormones are involved in the control of reproduction.

AB - Thyroid hormones, acting via their cognate thyroid receptors (TRs) act as mediators and modulators of several physiological processes and homeostasis. A clear role for the TRs in reproduction has not yet been established although several lines of recent evidence suggest that they are involved in the regulation of reproduction. To further study the role of TRs in control of reproduction, we investigated homologous regulation of TR subtypes in the gonads of goldfish, in vivo and in vitro. It was found that tri-iodothyronine (T3) down-regulates the traditional TRs (TRα-1 and TRβ) and up-regulates a dominant-negative form, TRα-t. This indicates a 'feedback' mechanism whereby an acute treatment with T3 down regulates further T3 mediated response. The results provide novel information on auto-regulation of TRs in the goldfish ovary and testis, and support the hypothesis that thyroid hormones are involved in the control of reproduction.

KW - Goldfish

KW - Gonads

KW - Regulation

KW - Reproduction

KW - Thyroid hormone

KW - Thyroid receptor

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Auto-regulation of thyroid hormone receptors in the goldfish ovary and testis

Abstract

Keywords

ASJC Scopus subject areas

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