Auditory system dysfunction in Alzheimer disease and its prodromal states

A review

Gabriel M. Swords, Lydia T. Nguyen, Raksha Mudar, Daniel Adolfo Llano

Research output: Contribution to journalReview article

Abstract

Recent findings suggest that both peripheral and central auditory system dysfunction occur in the prodromal stages of Alzheimer Disease (AD), and therefore may represent early indicators of the disease. In addition, loss of auditory function itself leads to communication difficulties, social isolation and poor quality of life for both patients with AD and their caregivers. Developing a greater understanding of auditory dysfunction in early AD may shed light on the mechanisms of disease progression and carry diagnostic and therapeutic importance. Herein, we review the literature on hearing abilities in AD and its prodromal stages investigated through methods such as pure-tone audiometry, dichotic listening tasks, and evoked response potentials. We propose that screening for peripheral and central auditory dysfunction in at-risk populations is a low-cost and effective means to identify early AD pathology and provides an entry point for therapeutic interventions that enhance the quality of life of AD patients.

Original languageEnglish (US)
Pages (from-to)49-59
Number of pages11
JournalAgeing Research Reviews
Volume44
DOIs
StatePublished - Jul 1 2018

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Prodromal Symptoms
Alzheimer Disease
Central Auditory Diseases
Quality of Life
Pure-Tone Audiometry
Social Isolation
Aptitude
Evoked Potentials
Caregivers
Hearing
Disease Progression
Audition
Pathology
Communication
Costs and Cost Analysis
Screening
Therapeutics

Keywords

  • Audiometry
  • Auditory cortex
  • Dichotic
  • Evoked potential
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

Cite this

Auditory system dysfunction in Alzheimer disease and its prodromal states : A review. / Swords, Gabriel M.; Nguyen, Lydia T.; Mudar, Raksha; Llano, Daniel Adolfo.

In: Ageing Research Reviews, Vol. 44, 01.07.2018, p. 49-59.

Research output: Contribution to journalReview article

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