Au nanoparticles target cancer

Prashant K. Jain, Ivan H. ElSayed, Mostafa A. El-Sayed

Research output: Contribution to journalReview article

Abstract

Nanoparticles with unique optical properties, facile surface chemistry, and appropriate size scale are generating much enthusiasm in molecular biology and medicine. Noble metal, especially Au, nanoparticles have immense potential for cancer diagnosis and therapy on account of their surface plasmon resonance (SPR) enhanced light scattering and absorption. Conjugation of Au nanoparticles to ligands specifically targeted to biomarkers on cancer cells allows molecular-specific imaging and detection of cancer. Additionally, Au nanoparticles efficiently convert the strongly absorbed light into localized heat, which can be exploited for the selective laser photothermal therapy of cancer. We discuss recent advances in the study and use of selectively targeted Au nanospheres in cancer photodiagnostics and photothermal therapy. By changing the shape or composition of Au nanoparticles, the SPR can be tuned to the near-infrared region, allowing in vivo imaging and photothermal therapy of cancer. The use of Au nanorods and silica-Au core-shell nanoparticles for in vivo cancer detection and therapy is discussed.

Original languageEnglish (US)
Pages (from-to)18-29
Number of pages12
JournalNano Today
Volume2
Issue number1
DOIs
StatePublished - Feb 2007
Externally publishedYes

Fingerprint

Nanoparticles
Neoplasms
Surface Plasmon Resonance
Surface plasmon resonance
Nanospheres
Molecular Medicine
Imaging techniques
Light
Nanotubes
Molecular biology
Molecular Imaging
Surface Properties
Laser Therapy
Biomarkers
Therapeutics
Tumor Biomarkers
Precious metals
Surface chemistry
Nanorods
Silicon Dioxide

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

Au nanoparticles target cancer. / Jain, Prashant K.; ElSayed, Ivan H.; El-Sayed, Mostafa A.

In: Nano Today, Vol. 2, No. 1, 02.2007, p. 18-29.

Research output: Contribution to journalReview article

Jain, PK, ElSayed, IH & El-Sayed, MA 2007, 'Au nanoparticles target cancer', Nano Today, vol. 2, no. 1, pp. 18-29. https://doi.org/10.1016/S1748-0132(07)70016-6
Jain, Prashant K. ; ElSayed, Ivan H. ; El-Sayed, Mostafa A. / Au nanoparticles target cancer. In: Nano Today. 2007 ; Vol. 2, No. 1. pp. 18-29.
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