TY - JOUR
T1 - Au nanoparticles target cancer
AU - Jain, Prashant K.
AU - ElSayed, Ivan H.
AU - El-Sayed, Mostafa A.
N1 - We acknowledge the contributions of Xiaohua Huang and Wei Qian in the Laser Dynamics Lab, Georgia Institute of Technology to work included in this review, and the following people for use of their facilities and support: Paul Edmonds, Mohan Srinivasarao, Rob Dickson, Lynn Peyser, Sandeep Patel, and Jie Zheng at Georgia Institute of Technology, Randall Kramer and Oren Humstoe at the Oral Cancer Research Center, University of California, San Francisco, and Patrica Leake and Russell Snyder in the Epstein Laboratory, University of California, San Francisco. We also acknowledge the financial support of the Chemical Science, Geosciences, and Bioscience Division of the Department of Energy (NO DE-FG02-97 ER14799) for the research included here. We acknowledge the financial support of the Hearing Research Institute.
PY - 2007/2
Y1 - 2007/2
N2 - Nanoparticles with unique optical properties, facile surface chemistry, and appropriate size scale are generating much enthusiasm in molecular biology and medicine. Noble metal, especially Au, nanoparticles have immense potential for cancer diagnosis and therapy on account of their surface plasmon resonance (SPR) enhanced light scattering and absorption. Conjugation of Au nanoparticles to ligands specifically targeted to biomarkers on cancer cells allows molecular-specific imaging and detection of cancer. Additionally, Au nanoparticles efficiently convert the strongly absorbed light into localized heat, which can be exploited for the selective laser photothermal therapy of cancer. We discuss recent advances in the study and use of selectively targeted Au nanospheres in cancer photodiagnostics and photothermal therapy. By changing the shape or composition of Au nanoparticles, the SPR can be tuned to the near-infrared region, allowing in vivo imaging and photothermal therapy of cancer. The use of Au nanorods and silica-Au core-shell nanoparticles for in vivo cancer detection and therapy is discussed.
AB - Nanoparticles with unique optical properties, facile surface chemistry, and appropriate size scale are generating much enthusiasm in molecular biology and medicine. Noble metal, especially Au, nanoparticles have immense potential for cancer diagnosis and therapy on account of their surface plasmon resonance (SPR) enhanced light scattering and absorption. Conjugation of Au nanoparticles to ligands specifically targeted to biomarkers on cancer cells allows molecular-specific imaging and detection of cancer. Additionally, Au nanoparticles efficiently convert the strongly absorbed light into localized heat, which can be exploited for the selective laser photothermal therapy of cancer. We discuss recent advances in the study and use of selectively targeted Au nanospheres in cancer photodiagnostics and photothermal therapy. By changing the shape or composition of Au nanoparticles, the SPR can be tuned to the near-infrared region, allowing in vivo imaging and photothermal therapy of cancer. The use of Au nanorods and silica-Au core-shell nanoparticles for in vivo cancer detection and therapy is discussed.
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U2 - 10.1016/S1748-0132(07)70016-6
DO - 10.1016/S1748-0132(07)70016-6
M3 - Review article
AN - SCOPUS:33846670191
SN - 1748-0132
VL - 2
SP - 18
EP - 29
JO - Nano Today
JF - Nano Today
IS - 1
ER -