Asymmetric total synthesis of cylindrocyclophanes A and F through Cyclodimerization and a Ramberg-Bäcklund Reaction

K. C. Nicolaou, Ya Ping Sun, Henry Korman, David Sarlah

Research output: Contribution to journalArticlepeer-review

Abstract

(Figure Presented) Two make a cycle: A Ramberg-Bäcklund reaction was employed to form the macrocyclic carbon skeleton of the marine natural products cylindrocyclophanes A and F in an asymmetric synthesis through a head-to-tail dimerization approach (see scheme).

Original languageEnglish (US)
Pages (from-to)5875-5878
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number34
DOIs
StatePublished - Aug 9 2010
Externally publishedYes

Keywords

  • Cklund reaction
  • Cyclodimerization
  • Natural products
  • RambergBä
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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