Asymmetric total synthesis of cylindrocyclophanes A and F through Cyclodimerization and a Ramberg-Bäcklund Reaction

K. C. Nicolaou; Ya Ping Sun; Henry Korman; David Sarlah

doi:10.1002/anie.201003500

Asymmetric total synthesis of cylindrocyclophanes A and F through Cyclodimerization and a Ramberg-Bäcklund Reaction

K. C. Nicolaou, Ya Ping Sun, Henry Korman, David Sarlah

Research output: Contribution to journal › Article › peer-review

Abstract

(Figure Presented) Two make a cycle: A Ramberg-Bäcklund reaction was employed to form the macrocyclic carbon skeleton of the marine natural products cylindrocyclophanes A and F in an asymmetric synthesis through a head-to-tail dimerization approach (see scheme).

Original language	English (US)
Pages (from-to)	5875-5878
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	34
DOIs	https://doi.org/10.1002/anie.201003500
State	Published - Aug 9 2010
Externally published	Yes

Keywords

Cklund reaction
Cyclodimerization
Natural products
RambergBä
Total synthesis

ASJC Scopus subject areas

Catalysis
General Chemistry

Online availability

10.1002/anie.201003500

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abstract = "(Figure Presented) Two make a cycle: A Ramberg-B{\"a}cklund reaction was employed to form the macrocyclic carbon skeleton of the marine natural products cylindrocyclophanes A and F in an asymmetric synthesis through a head-to-tail dimerization approach (see scheme).",

keywords = "Cklund reaction, Cyclodimerization, Natural products, RambergB{\"a}, Total synthesis",

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AU - Sun, Ya Ping

AU - Korman, Henry

AU - Sarlah, David

PY - 2010/8/9

Y1 - 2010/8/9

N2 - (Figure Presented) Two make a cycle: A Ramberg-Bäcklund reaction was employed to form the macrocyclic carbon skeleton of the marine natural products cylindrocyclophanes A and F in an asymmetric synthesis through a head-to-tail dimerization approach (see scheme).

AB - (Figure Presented) Two make a cycle: A Ramberg-Bäcklund reaction was employed to form the macrocyclic carbon skeleton of the marine natural products cylindrocyclophanes A and F in an asymmetric synthesis through a head-to-tail dimerization approach (see scheme).

KW - Cklund reaction

KW - Cyclodimerization

KW - Natural products

KW - RambergBä

KW - Total synthesis

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Asymmetric total synthesis of cylindrocyclophanes A and F through Cyclodimerization and a Ramberg-Bäcklund Reaction

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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