Asymmetric Construction of Quaternary Centers by Enantioselective Allylation: Application to the Synthesis of the Serotonin Antagonist LY426965

Scott E Denmark, Jiping Fu

Research output: Contribution to journalArticle

Abstract

(Matrix Presented) Catalytic enantioselective allylation with a chiral bisphosphoramide was applied to the synthesis of LY426965, a serotonin antagonist. The key step, addition of a 3,3-disubstituted allyltrichlorosilane to benzaldehyde, provided the adduct containing a stereogenic quaternary center with excellent diastereoselectivity and enantioselectivity.

Original languageEnglish (US)
Pages (from-to)1951-1953
Number of pages3
JournalOrganic Letters
Volume4
Issue number11
DOIs
StatePublished - May 30 2002

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ASJC Scopus subject areas

  • Molecular Medicine

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