TY - JOUR
T1 - Associations of Prenatal Exposure to Phthalates with Measures of Cognition in 4.5-Month-Old Infants
AU - Merced-Nieves, Francheska M.
AU - Dzwilewski, Kelsey L. C.
AU - Aguiar, Andrea
AU - Musaad, Salma
AU - Korrick, Susan A.
AU - Schantz, Susan L.
N1 - Funding Information:
This research was supported by the Children?s Environmental Health and Disease Prevention Research Centers, National Institute of Environmental Health Sciences under grant ES022848; U.S. Environmental Health Protection Agency under grant RD83543401; the Environmental Influences on Child Health Outcomes (ECHO) under grant OD023272; and the NIH Predoctoral Traineeship in Endocrine, Developmental and Reproductive Toxicology under grant T32 ES007326.We are grateful to the mothers and infants who participated in the Illinois Kids Development Study (IKIDS). We are also grateful for the research staff and coordinators of the study without whom this work would not be possible.
Funding Information:
Funding: This research was supported by the Children’s Environmental Health and Disease Prevention Research Centers, National Institute of Environmental Health Sciences under grant ES022848; U.S. Environmental Health Protection Agency under grant RD83543401; the Environmental Influences on Child Health Outcomes (ECHO) under grant OD023272; and the NIH Predoctoral Traineeship in Endocrine, Developmental and Reproductive Toxicology under grant T32 ES007326.
PY - 2021/2/2
Y1 - 2021/2/2
N2 - The association of prenatal phthalate exposure with physical reasoning was assessed in 159 (78 female; 81 male) 4.5-month-old infants from a prospective cohort. Phthalate metabolites were quantified in urine from 16–18 gestational weeks and a pool of five urines from across pregnancy. Infants’ looking times to physically impossible and possible events were recorded via infrared eye-tracking. Infants that recognize that one of the events is impossible will look at that event longer. Associations of phthalate biomarkers with looking time differences (impossible–possible) were adjusted for maternal age, infant sex, and order of event presentation, and effect modification by infant sex was assessed. Each interquartile range (IQR) increase of monoethyl phthalate in the pooled sample was associated with females’ increased looking time (β = 1.0; 95%CI = 0.3, 1.7 s) to the impossible event. However, for males, an IQR increase in monoethyl phthalate at 16–18 weeks (β = −2.5; 95%CI = −4.4,−0.6 s), the sum of di(isononyl) phthalate metabolites in the pooled sample (β = −1.0; 95%CI = −1.8, −0.1 s), and the sum of all phthalate metabolites in both samples (β = −2.3; 95%CI = −4.4, −0.2 s) were associated with increased looking to the possible event, suggesting that higher prenatal phthalate exposure is associated with poorer physical reasoning in male infants.
AB - The association of prenatal phthalate exposure with physical reasoning was assessed in 159 (78 female; 81 male) 4.5-month-old infants from a prospective cohort. Phthalate metabolites were quantified in urine from 16–18 gestational weeks and a pool of five urines from across pregnancy. Infants’ looking times to physically impossible and possible events were recorded via infrared eye-tracking. Infants that recognize that one of the events is impossible will look at that event longer. Associations of phthalate biomarkers with looking time differences (impossible–possible) were adjusted for maternal age, infant sex, and order of event presentation, and effect modification by infant sex was assessed. Each interquartile range (IQR) increase of monoethyl phthalate in the pooled sample was associated with females’ increased looking time (β = 1.0; 95%CI = 0.3, 1.7 s) to the impossible event. However, for males, an IQR increase in monoethyl phthalate at 16–18 weeks (β = −2.5; 95%CI = −4.4,−0.6 s), the sum of di(isononyl) phthalate metabolites in the pooled sample (β = −1.0; 95%CI = −1.8, −0.1 s), and the sum of all phthalate metabolites in both samples (β = −2.3; 95%CI = −4.4, −0.2 s) were associated with increased looking to the possible event, suggesting that higher prenatal phthalate exposure is associated with poorer physical reasoning in male infants.
KW - Neurodevelopment
KW - Phthalates
KW - Sexually dimorphic
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U2 - 10.3390/ijerph18041838
DO - 10.3390/ijerph18041838
M3 - Article
C2 - 33668677
SN - 1660-4601
VL - 18
SP - 1
EP - 13
JO - International journal of environmental research and public health
JF - International journal of environmental research and public health
IS - 4
M1 - 1838
ER -