Associations between reported on-farm antimicrobial use practices and observed antimicrobial resistance in generic fecal Escherichia coli isolated from Alberta finishing swine farms

Csaba Varga; Andrijana Rajić; Margaret E. McFall; Richard J. Reid-Smith; Anne E. Deckert; Sylvia L. Checkley; Scott A. McEwen

doi:10.1016/j.prevetmed.2008.10.002

Associations between reported on-farm antimicrobial use practices and observed antimicrobial resistance in generic fecal Escherichia coli isolated from Alberta finishing swine farms

Csaba Varga, Andrijana Rajić, Margaret E. McFall, Richard J. Reid-Smith, Anne E. Deckert, Sylvia L. Checkley, Scott A. McEwen

Research output: Contribution to journal › Article › peer-review

Abstract

Multilevel random intercept logistic and Poisson regression were used to model associations between various antimicrobial use practices and resistance to individual and multiple antimicrobials among generic fecal Escherichia coli isolated from Alberta finishing swine. In-feed antimicrobial use in finishers was significantly associated with increased risk of resistance to ampicillin, chloramphenicol, streptomycin, and sulfisoxazole in generic E. coli isolates. Chlortetracycline use in grower rations was associated with ampicillin and tetracycline resistance. Use of in-feed antimicrobials in finishers was significantly associated with increased risk of resistance of generic E. coli to multiple antimicrobials. The study findings suggest that certain farm-level interventions related to antimicrobial use might be beneficial in reducing development and emergence of antimicrobial resistance in swine populations.

Original language	English (US)
Pages (from-to)	185-192
Number of pages	8
Journal	Preventive Veterinary Medicine
Volume	88
Issue number	3
DOIs	https://doi.org/10.1016/j.prevetmed.2008.10.002
State	Published - Mar 1 2009
Externally published	Yes

Keywords

Antimicrobial resistance
Antimicrobial use practices
Escherichia coli
Multidrug-resistance
Risk factors
Swine

ASJC Scopus subject areas

Food Animals
Animal Science and Zoology

Online availability

10.1016/j.prevetmed.2008.10.002

Library availability

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Varga, C., Rajić, A., McFall, M. E., Reid-Smith, R. J., Deckert, A. E., Checkley, S. L., & McEwen, S. A. (2009). Associations between reported on-farm antimicrobial use practices and observed antimicrobial resistance in generic fecal Escherichia coli isolated from Alberta finishing swine farms. Preventive Veterinary Medicine, 88(3), 185-192. https://doi.org/10.1016/j.prevetmed.2008.10.002

Associations between reported on-farm antimicrobial use practices and observed antimicrobial resistance in generic fecal Escherichia coli isolated from Alberta finishing swine farms. / Varga, Csaba; Rajić, Andrijana; McFall, Margaret E. et al.
In: Preventive Veterinary Medicine, Vol. 88, No. 3, 01.03.2009, p. 185-192.

Research output: Contribution to journal › Article › peer-review

Varga, C, Rajić, A, McFall, ME, Reid-Smith, RJ, Deckert, AE, Checkley, SL & McEwen, SA 2009, 'Associations between reported on-farm antimicrobial use practices and observed antimicrobial resistance in generic fecal Escherichia coli isolated from Alberta finishing swine farms', Preventive Veterinary Medicine, vol. 88, no. 3, pp. 185-192. https://doi.org/10.1016/j.prevetmed.2008.10.002

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abstract = "Multilevel random intercept logistic and Poisson regression were used to model associations between various antimicrobial use practices and resistance to individual and multiple antimicrobials among generic fecal Escherichia coli isolated from Alberta finishing swine. In-feed antimicrobial use in finishers was significantly associated with increased risk of resistance to ampicillin, chloramphenicol, streptomycin, and sulfisoxazole in generic E. coli isolates. Chlortetracycline use in grower rations was associated with ampicillin and tetracycline resistance. Use of in-feed antimicrobials in finishers was significantly associated with increased risk of resistance of generic E. coli to multiple antimicrobials. The study findings suggest that certain farm-level interventions related to antimicrobial use might be beneficial in reducing development and emergence of antimicrobial resistance in swine populations.",

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AU - Reid-Smith, Richard J.

AU - Deckert, Anne E.

AU - Checkley, Sylvia L.

AU - McEwen, Scott A.

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AB - Multilevel random intercept logistic and Poisson regression were used to model associations between various antimicrobial use practices and resistance to individual and multiple antimicrobials among generic fecal Escherichia coli isolated from Alberta finishing swine. In-feed antimicrobial use in finishers was significantly associated with increased risk of resistance to ampicillin, chloramphenicol, streptomycin, and sulfisoxazole in generic E. coli isolates. Chlortetracycline use in grower rations was associated with ampicillin and tetracycline resistance. Use of in-feed antimicrobials in finishers was significantly associated with increased risk of resistance of generic E. coli to multiple antimicrobials. The study findings suggest that certain farm-level interventions related to antimicrobial use might be beneficial in reducing development and emergence of antimicrobial resistance in swine populations.

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KW - Antimicrobial use practices

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KW - Multidrug-resistance

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Associations between reported on-farm antimicrobial use practices and observed antimicrobial resistance in generic fecal Escherichia coli isolated from Alberta finishing swine farms

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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