Abstract
Limited studies examine how prenatal environmental and social exposures jointly impact perinatal health. Here we investigated relationships between a neighborhood-level combined exposure (CE) index assessed during pregnancy and perinatal outcomes, including birthweight, gestational age, and preterm birth. Across all participants, higher CE index scores were associated with small decreases in birthweight and gestational age. We also observed effect modification by race; infants born to Black pregnant people had a greater risk of preterm birth for higher CE values compared to White infants. Overall, our results suggest that neighborhood social and environmental exposures have a small but measurable joint effect on neonatal indicators of health.
| Original language | English (US) |
|---|---|
| Article number | 102858 |
| Journal | Health and Place |
| Volume | 76 |
| DOIs | |
| State | Published - Jul 2022 |
Keywords
- Environmental hazards
- Neighborhoods
- Perinatal health
- Prenatal
- Social stressors
ASJC Scopus subject areas
- Health(social science)
- Sociology and Political Science
- Life-span and Life-course Studies
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In: Health and Place, Vol. 76, 102858, 07.2022.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Associations between combined exposure to environmental hazards and social stressors at the neighborhood level and individual perinatal outcomes in the ECHO-wide cohort
AU - on behalf of Program Collaborators for Environmental Influences on Child Health Outcomes
AU - Martenies, Sheena E.
AU - Zhang, Mingyu
AU - Corrigan, Anne E.
AU - Kvit, Anton
AU - Shields, Timothy
AU - Wheaton, William
AU - Bastain, Theresa M.
AU - Breton, Carrie V.
AU - Dabelea, Dana
AU - Habre, Rima
AU - Magzamen, Sheryl
AU - Padula, Amy M.
AU - Him, Deana Around
AU - Camargo, Carlos A.
AU - Cowell, Whitney
AU - Croen, Lisa A.
AU - Deoni, Sean
AU - Everson, Todd M.
AU - Hartert, Tina V.
AU - Hipwell, Alison E.
AU - McEvoy, Cindy T.
AU - Morello-Frosch, Rachel
AU - O'Connor, Thomas G.
AU - Petriello, Michael
AU - Sathyanarayana, Sheela
AU - Stanford, Joseph B.
AU - Woodruff, Tracey J.
AU - Wright, Rosalind J.
AU - Kress, Amii M.
N1 - Funding Information: Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health , under Award Numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (PRO Core), UH3 OD023320 (Aschner, J), UH3 OD023253 (Camargo, C), UH3 OD023248 (Dabelea, D), UH3 OD023313 , Deoni, S), UH3 OD023318 (Dunlop, A), UH3 OD023279 (Elliott, A), UH3 OD023289 (Ferrara, A), UH3 OD023282 (Gern, J), UH3 OD023287 (Breton, C), UH3 OD023365 (Hertz-Picciotto, I), UH3 OD023275 (Karagas, M), UH3 OD023271 (Karr, C), UH3 OD023347 (Lester, B), UH3 OD023268 (Weiss, S), UH3 OD023288 (McEvoy, C), UH3 OD023342 (Newschaffer, C), UH3 OD023285 (Kerver, J), UH3 OD023272 (Schantz, S), UH3 OD023249 (Stanford, J), UH3 OD023305 (Trasande, L), UH3 OD023337 (Wright, R), UH3OD023328 (Duarte), UH3OD023342 (Lyall), UH3OD023349 (O’Connor), and UH3 OD023244 (Hipwell, A, Keenan K). Funding Information: The authors wish to thank our ECHO colleagues, the medical, nursing and program staff, as well as the children and families participating in the ECHO cohorts. We also acknowledge the contribution of the following ECHO program collaborators:, 1.Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL, Benjamin DK. 2.Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Parker CB. 3. ECHO Awardees and Cohorts: Albert Einstein College of Medicine, Bronx, New York: Aschner J, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio: Merhar S, Indiana University, Riley Hospital for Children, Indianapolis, IN: Ren C, University of Rochester Medical Center, Rochester, NY: Pryhuber G, Vanderbilt Children's Hospital, Nashville, TN: Moore P, Florida Hospital for Children, Orlando, FL: Wadhawan, R, Medical University of South Carolina, Charleston, SC: Wagner C, University of Arkansas for Medical Science: Keller R, University of Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY: Reynolds A, University California, San Francisco: Keller R, University of Florida College of Medicine, Jacksonville, FL: Hudak M, University of Texas Health Sciences Center, Houston, TX: Duncan A, Wake Forest University School of Medicine, Winston Salem, NC: Walshburn L, Icahn School of Medicine at Mount Sinai, New York, NY: Teitelbaum SL; Stroustrup A, Cohen Children's Medical Center, Northwell Health: Stroustrup A, Children's Hospital and Clinic Minneapolis, MN: Lampland A, University of Washington, Seattle, WA: Mayock D, Boston Children's Hospital, Boston, MA: Mansbach J, Children's Hospital of Philadelphia, Philadelphia, PA: Spergel J, Norton Children's Hospital, Louisville, KY: Stevenson M, Phoenix Children's Hospital, Phoenix AZ: Bauer C, Emory University, Atlanta, GA: Dunlop A, Avera Health Rapid City, Rapid City, SD: Elliott A, Kaiser Permanente Northern California Division of Research, Oakland, CA: Ferrara A, University of Wisconsin, Madison WI: Gern J, Marshfield Clinic Research Institute, Marshfield, WI: Seroogy C: Bendixsen C, University of California Davis Mind Institute, Sacramento, CA: Hertz-Picciotto I, Geisel School of Medicine at Dartmouth, Lebanon, NH: Karagas M, University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, WA: Karr C, University of Tennessee Health Science Center, Memphis, TN: Mason A, Brigham and Women's Hospital, Boston, MA: Weiss S, Boston University Medical Center, Boston, MA: O'Connor G, Kaiser Permanente, Southern California, San Diego, CA: Zeiger R, Washington University of St. Louis, St Louis, MO: Bacharier L, Women & Infants Hospital of Rhode Island, Providence RI, Lester B, Children's Mercy, Kansas City, MO: Carter B, Emory University, Atlanta, GA: Marsit C, Helen DeVos, Children's Hospital, Grand Rapids, MI: Pastyrnak S, Kapiolani Medical Center for Women and Children, Providence, RI: Neal C, Los Angeles Biomedical Research Institute at Harbour-UCLA Medical Center, Los Angeles CA: Smith L, Wake Forest University School of Medicine, Winston Salem, NC: Helderman J Indiana University, Riley Hospital for Children: Indianapolis, IN, Tepper R, Pennsylvania State University, University Park, PA:Craig Newschaffer, Johns Hopkins Bloomberg School of Public Health: Volk H, University of California, Davis Medical Center - MIND Institute: Schmidt R, Michigan State University, East Lansing, MI: Kerver J, Henry Ford Health System, Detroit, MI: Barone, C, Michigan Department of Health and Human Services, Lansing, MI: McKane, P, Michigan State University, East Lansing, MI: Paneth N, University of Michigan, Ann Arbor, MI: Elliott, M, University of Illinois, Beckman Institute, Urbana, IL: Schantz S, University of Utah, Salt Lake City, UT: Porucznik C, University of Utah, Salt Lake City, UT: Silver R, University of Utah, Salt Lake City, UT: Conradt E, New York School of Medicine, New York, NY: Trasande L, Boston Children's Hospital, Boston MA: Bosquet-Enlow M, George Mason University, Fairfax, VA: Huddleston K, University of California, San Francisco, San Francisco CA: Bush N, University of Minnesota, Minneapolis, MN: Nguyen R, University of Rochester Medical Center: Rochester, NY: Barrett E, University of Pittsburgh, Pennsylvania: Hipwell AE, Keenan KE, New York State Psychiatric Institute, New York, NY: Duarte C, University of Puerto Rico, San Jaun, PR: Canino G, University of Washington: Dager S, Children's Hospital of Philadelphia - Center for Autism Research: Schultz R, University of North Carolina at Chapel Hill: Piven J. University of Pittsburgh Medical Center, Magee Women's Hospital, Pittsburgh, PA: Simhan H, University of Southern California, Los Angeles, CA: Gilliland F; Farzan S; Bastain T. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of The Director, National Institutes of Health, under Award Numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (PRO Core), UH3 OD023320 (Aschner, J), UH3 OD023253 (Camargo, C), UH3 OD023248 (Dabelea, D), UH3 OD023313, Deoni, S), UH3 OD023318 (Dunlop, A), UH3 OD023279 (Elliott, A), UH3 OD023289 (Ferrara, A), UH3 OD023282 (Gern, J), UH3 OD023287 (Breton, C), UH3 OD023365 (Hertz-Picciotto, I), UH3 OD023275 (Karagas, M), UH3 OD023271 (Karr, C), UH3 OD023347 (Lester, B), UH3 OD023268 (Weiss, S), UH3 OD023288 (McEvoy, C), UH3 OD023342 (Newschaffer, C), UH3 OD023285 (Kerver, J), UH3 OD023272 (Schantz, S), UH3 OD023249 (Stanford, J), UH3 OD023305 (Trasande, L), UH3 OD023337 (Wright, R), UH3OD023328 (Duarte), UH3OD023342 (Lyall), UH3OD023349 (O'Connor), and UH3 OD023244 (Hipwell, A, Keenan K). Publisher Copyright: © 2022 Elsevier Ltd
PY - 2022/7
Y1 - 2022/7
N2 - Limited studies examine how prenatal environmental and social exposures jointly impact perinatal health. Here we investigated relationships between a neighborhood-level combined exposure (CE) index assessed during pregnancy and perinatal outcomes, including birthweight, gestational age, and preterm birth. Across all participants, higher CE index scores were associated with small decreases in birthweight and gestational age. We also observed effect modification by race; infants born to Black pregnant people had a greater risk of preterm birth for higher CE values compared to White infants. Overall, our results suggest that neighborhood social and environmental exposures have a small but measurable joint effect on neonatal indicators of health.
AB - Limited studies examine how prenatal environmental and social exposures jointly impact perinatal health. Here we investigated relationships between a neighborhood-level combined exposure (CE) index assessed during pregnancy and perinatal outcomes, including birthweight, gestational age, and preterm birth. Across all participants, higher CE index scores were associated with small decreases in birthweight and gestational age. We also observed effect modification by race; infants born to Black pregnant people had a greater risk of preterm birth for higher CE values compared to White infants. Overall, our results suggest that neighborhood social and environmental exposures have a small but measurable joint effect on neonatal indicators of health.
KW - Environmental hazards
KW - Neighborhoods
KW - Perinatal health
KW - Prenatal
KW - Social stressors
UR - http://www.scopus.com/inward/record.url?scp=85134737933&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85134737933&partnerID=8YFLogxK
U2 - 10.1016/j.healthplace.2022.102858
DO - 10.1016/j.healthplace.2022.102858
M3 - Article
C2 - 35872389
AN - SCOPUS:85134737933
SN - 1353-8292
VL - 76
JO - Health and Place
JF - Health and Place
M1 - 102858
ER -