Association of perfluoroalkyl substances exposure with impaired lung function in children

Xiao Di Qin; Zhengmin (Min) Qian; Shyamali C. Dharmage; Jennifer Perret; Sarah Dee Geiger; Steven E. Rigdon; Steven Howard; Xiao Wen Zeng; Li Wen Hu; Bo Yi Yang; Yang Zhou; Meng Li; Shu Li Xu; Wen Wen Bao; Ya Zhi Zhang; Ping Yuan; Jia Wang; Chuan Zhang; Yan Peng Tian; Min Nian; Xiang Xiao; Wen Chen; Yungling Leo Lee; Guang Hui Dong

doi:10.1016/j.envres.2017.01.025

Association of perfluoroalkyl substances exposure with impaired lung function in children

Xiao Di Qin, Zhengmin (Min) Qian, Shyamali C. Dharmage, Jennifer Perret, Sarah Dee Geiger, Steven E. Rigdon, Steven Howard, Xiao Wen Zeng, Li Wen Hu, Bo Yi Yang, Yang Zhou, Meng Li, Shu Li Xu, Wen Wen Bao, Ya Zhi Zhang, Ping Yuan, Jia Wang, Chuan Zhang, Yan Peng Tian, Min NianXiang Xiao, Wen Chen, Yungling Leo Lee, Guang Hui Dong

Research output: Contribution to journal › Article › peer-review

Abstract

Previous studies have demonstrated associations between serum levels of perfluoroalkyl substances (PFASs) and asthma or asthma related-biomarkers. However, no studies have reported a possible relationship between PFASs exposure and lung function among children. The objective of the present study is to test the association between PFASs exposure and lung function in children from a high exposure area by using a cross-sectional case-control study, which included 132 asthmatic children and 168 non-asthmatic controls recruited from 2009 to 2010 in the Genetic and Biomarkers study for Childhood Asthma. Structured questionnaires were administered face-to-face. Lung function was measured by spirometry. Linear regression models were used to examine the influence of PFASs on lung function. The results showed that asthmatics in our study had significantly higher serum PFAS concentrations than healthy controls. Logistic regression models showed a positive association between PFASs and asthma, with adjusted odds ratios (ORs) ranging from 0.99 (95% confidence interval [CI]: 0.80–1.21) to 2.76 (95% CI: 1.82–4.17). Linear regression modeling showed serum PFASs levels were significantly negatively associated with three pulmonary function measurements (forced vital capacity: FVC; forced expiratory volume in 1 s: FEV₁; forced expiratory flow 25–75%: FEF_25–75) among children with asthma, the adjusted coefficients between lung function and PFASs exposure ranged from −0.055 (95%CI: −0.100 to −0.010) for FVC and perfluorooctane sulfonate (PFOS) to −0.223 (95%CI: −0.400 to −0.045) for FEF_25–75and perfluorooctanoic acid (PFOA). PFASs were not, however, significantly associated with pulmonary function among children without asthma. In conclusion, this study suggests that serum PFASs are associated with decreased lung function among children with asthma.

Original language	English (US)
Pages (from-to)	15-21
Number of pages	7
Journal	Environmental Research
Volume	155
DOIs	https://doi.org/10.1016/j.envres.2017.01.025
State	Published - 2017
Externally published	Yes

Keywords

Asthma
Children
Lung function
Perfluoroalkyl substances

ASJC Scopus subject areas

Biochemistry
General Environmental Science

Online availability

10.1016/j.envres.2017.01.025

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Qin, X. D., Qian, Z., Dharmage, S. C., Perret, J., Geiger, S. D., Rigdon, S. E., Howard, S., Zeng, X. W., Hu, L. W., Yang, B. Y., Zhou, Y., Li, M., Xu, S. L., Bao, W. W., Zhang, Y. Z., Yuan, P., Wang, J., Zhang, C., Tian, Y. P., ... Dong, G. H. (2017). Association of perfluoroalkyl substances exposure with impaired lung function in children. Environmental Research, 155, 15-21. https://doi.org/10.1016/j.envres.2017.01.025

Qin, XD, Qian, Z, Dharmage, SC, Perret, J, Geiger, SD, Rigdon, SE, Howard, S, Zeng, XW, Hu, LW, Yang, BY, Zhou, Y, Li, M, Xu, SL, Bao, WW, Zhang, YZ, Yuan, P, Wang, J, Zhang, C, Tian, YP, Nian, M, Xiao, X, Chen, W, Lee, YL & Dong, GH 2017, 'Association of perfluoroalkyl substances exposure with impaired lung function in children', Environmental Research, vol. 155, pp. 15-21. https://doi.org/10.1016/j.envres.2017.01.025

@article{700a49e570c9414787da69883154b667,

title = "Association of perfluoroalkyl substances exposure with impaired lung function in children",

abstract = "Previous studies have demonstrated associations between serum levels of perfluoroalkyl substances (PFASs) and asthma or asthma related-biomarkers. However, no studies have reported a possible relationship between PFASs exposure and lung function among children. The objective of the present study is to test the association between PFASs exposure and lung function in children from a high exposure area by using a cross-sectional case-control study, which included 132 asthmatic children and 168 non-asthmatic controls recruited from 2009 to 2010 in the Genetic and Biomarkers study for Childhood Asthma. Structured questionnaires were administered face-to-face. Lung function was measured by spirometry. Linear regression models were used to examine the influence of PFASs on lung function. The results showed that asthmatics in our study had significantly higher serum PFAS concentrations than healthy controls. Logistic regression models showed a positive association between PFASs and asthma, with adjusted odds ratios (ORs) ranging from 0.99 (95% confidence interval [CI]: 0.80–1.21) to 2.76 (95% CI: 1.82–4.17). Linear regression modeling showed serum PFASs levels were significantly negatively associated with three pulmonary function measurements (forced vital capacity: FVC; forced expiratory volume in 1 s: FEV1; forced expiratory flow 25–75%: FEF25–75) among children with asthma, the adjusted coefficients between lung function and PFASs exposure ranged from −0.055 (95%CI: −0.100 to −0.010) for FVC and perfluorooctane sulfonate (PFOS) to −0.223 (95%CI: −0.400 to −0.045) for FEF25–75and perfluorooctanoic acid (PFOA). PFASs were not, however, significantly associated with pulmonary function among children without asthma. In conclusion, this study suggests that serum PFASs are associated with decreased lung function among children with asthma.",

keywords = "Asthma, Children, Lung function, Perfluoroalkyl substances",

author = "Qin, {Xiao Di} and Qian, {Zhengmin (Min)} and Dharmage, {Shyamali C.} and Jennifer Perret and Geiger, {Sarah Dee} and Rigdon, {Steven E.} and Steven Howard and Zeng, {Xiao Wen} and Hu, {Li Wen} and Yang, {Bo Yi} and Yang Zhou and Meng Li and Xu, {Shu Li} and Bao, {Wen Wen} and Zhang, {Ya Zhi} and Ping Yuan and Jia Wang and Chuan Zhang and Tian, {Yan Peng} and Min Nian and Xiang Xiao and Wen Chen and Lee, {Yungling Leo} and Dong, {Guang Hui}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

doi = "10.1016/j.envres.2017.01.025",

language = "English (US)",

volume = "155",

pages = "15--21",

journal = "Environmental Research",

issn = "0013-9351",

publisher = "Academic Press Inc.",

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T1 - Association of perfluoroalkyl substances exposure with impaired lung function in children

AU - Qin, Xiao Di

AU - Qian, Zhengmin (Min)

AU - Dharmage, Shyamali C.

AU - Perret, Jennifer

AU - Geiger, Sarah Dee

AU - Rigdon, Steven E.

AU - Howard, Steven

AU - Zeng, Xiao Wen

AU - Hu, Li Wen

AU - Yang, Bo Yi

AU - Zhou, Yang

AU - Li, Meng

AU - Xu, Shu Li

AU - Bao, Wen Wen

AU - Zhang, Ya Zhi

AU - Yuan, Ping

AU - Wang, Jia

AU - Zhang, Chuan

AU - Tian, Yan Peng

AU - Nian, Min

AU - Xiao, Xiang

AU - Chen, Wen

AU - Lee, Yungling Leo

AU - Dong, Guang Hui

PY - 2017

Y1 - 2017

N2 - Previous studies have demonstrated associations between serum levels of perfluoroalkyl substances (PFASs) and asthma or asthma related-biomarkers. However, no studies have reported a possible relationship between PFASs exposure and lung function among children. The objective of the present study is to test the association between PFASs exposure and lung function in children from a high exposure area by using a cross-sectional case-control study, which included 132 asthmatic children and 168 non-asthmatic controls recruited from 2009 to 2010 in the Genetic and Biomarkers study for Childhood Asthma. Structured questionnaires were administered face-to-face. Lung function was measured by spirometry. Linear regression models were used to examine the influence of PFASs on lung function. The results showed that asthmatics in our study had significantly higher serum PFAS concentrations than healthy controls. Logistic regression models showed a positive association between PFASs and asthma, with adjusted odds ratios (ORs) ranging from 0.99 (95% confidence interval [CI]: 0.80–1.21) to 2.76 (95% CI: 1.82–4.17). Linear regression modeling showed serum PFASs levels were significantly negatively associated with three pulmonary function measurements (forced vital capacity: FVC; forced expiratory volume in 1 s: FEV1; forced expiratory flow 25–75%: FEF25–75) among children with asthma, the adjusted coefficients between lung function and PFASs exposure ranged from −0.055 (95%CI: −0.100 to −0.010) for FVC and perfluorooctane sulfonate (PFOS) to −0.223 (95%CI: −0.400 to −0.045) for FEF25–75and perfluorooctanoic acid (PFOA). PFASs were not, however, significantly associated with pulmonary function among children without asthma. In conclusion, this study suggests that serum PFASs are associated with decreased lung function among children with asthma.

AB - Previous studies have demonstrated associations between serum levels of perfluoroalkyl substances (PFASs) and asthma or asthma related-biomarkers. However, no studies have reported a possible relationship between PFASs exposure and lung function among children. The objective of the present study is to test the association between PFASs exposure and lung function in children from a high exposure area by using a cross-sectional case-control study, which included 132 asthmatic children and 168 non-asthmatic controls recruited from 2009 to 2010 in the Genetic and Biomarkers study for Childhood Asthma. Structured questionnaires were administered face-to-face. Lung function was measured by spirometry. Linear regression models were used to examine the influence of PFASs on lung function. The results showed that asthmatics in our study had significantly higher serum PFAS concentrations than healthy controls. Logistic regression models showed a positive association between PFASs and asthma, with adjusted odds ratios (ORs) ranging from 0.99 (95% confidence interval [CI]: 0.80–1.21) to 2.76 (95% CI: 1.82–4.17). Linear regression modeling showed serum PFASs levels were significantly negatively associated with three pulmonary function measurements (forced vital capacity: FVC; forced expiratory volume in 1 s: FEV1; forced expiratory flow 25–75%: FEF25–75) among children with asthma, the adjusted coefficients between lung function and PFASs exposure ranged from −0.055 (95%CI: −0.100 to −0.010) for FVC and perfluorooctane sulfonate (PFOS) to −0.223 (95%CI: −0.400 to −0.045) for FEF25–75and perfluorooctanoic acid (PFOA). PFASs were not, however, significantly associated with pulmonary function among children without asthma. In conclusion, this study suggests that serum PFASs are associated with decreased lung function among children with asthma.

KW - Asthma

KW - Children

KW - Lung function

KW - Perfluoroalkyl substances

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ER -

Association of perfluoroalkyl substances exposure with impaired lung function in children

Abstract

Keywords

ASJC Scopus subject areas

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