Association of blood lactate concentration and outcome in foals

K. Wotman, P. A. Wilkins, J. E. Palmer, R. C. Boston

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Lactate concentration in blood or plasma ([LAC]) and change in [LAC] are associated with survival in sick foals. Hypothesis: [LAC] and change in [LAC] over time are associated with survival at 96 hours and discharge in neonatal foals. Furthermore [LAC] and change in [LAC] over time correlate with blood culture results and blood pressure at admission. Animals: Two hundred and twenty-five foals consecutively admitted to a Neonatal Intensive Care Unit. Methods: Retrospective case review. Foals ≤30 days of age with [LAC] from arterial (190) or umbilical (35) blood gas analysis ([LAC] BG) at admission, 24, and 48 hours. [LAC] BG, blood pressure, blood culture status, and outcome (survival versus nonsurvival at 96 hours and discharge) were recorded. Change in [LAC] BG over time ([LAC] BGδ) was calculated. Results: [LAC] BG was lower in survivors (96 hours and discharge) at all times. [LAC] BGδ was larger for survivors (96 hours). Odds of survival (96 hours and discharge) decreased 18, 39, 53 and 22, 38, and 47%, respectively, at each sample time for every 1 mmol/L increment in [LAC] BG and increased 156% for each 1.0/day increment in [LAC] BGδ from admission to 24 hours at 96 hours. Blood pressure and [LAC] BG were not correlated (P =.196) until removal of selected foals (mean arterial pressure <60mmHg, admission [LAC] BG <5.5mmol/L) (P <.001). Bacteremia was not associated with [LAC] BG. Proposed admission [LAC] BG cut-points for future studies were 6.5mmol/L (96 hours) and 5.5mmol/L (discharge). Conclusions and Clinical Importance: Prospective studies evaluating [LAC], [LAC] BGδ, and cut-points in sick foals are warranted.

Original languageEnglish (US)
Pages (from-to)598-605
Number of pages8
JournalJournal of veterinary internal medicine
Volume23
Issue number3
DOIs
StatePublished - May 2009

Keywords

  • Bacteremia
  • Clearance
  • Critical care
  • Hyperlactatemia
  • Prognosis
  • Sepsis

ASJC Scopus subject areas

  • veterinary(all)

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